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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Antagonist activity at recombinant mouse P2X1 receptor overexpressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM preincubated for 20 mins followed by ATP induction by two-electrode voltage clamping method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse P2X1 receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at recombinant mouse P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current preincubated for 20 mins followed by ATP addition by two-electrode voltage clamp assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity at recombinant mouse P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM preincubated for 20 mins followed by ATP addition by two-electrode voltage clamp assay relative to control
Assay data:22 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM incubated for 20 mins prior to ATP-induction by two-electrode voltage clamp assay
Assay data:7 Tested
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 100 nM incubated for 20 mins prior to ATP-induction by two-electrode voltage clamp assay
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current incubated for 20 mins prior to ATP-induction by two-electrode voltage clamp assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current incubated for 20 mins prior to ATP-induction measured after compound washout by two-electrode voltage clamp assay
Antagonist activity at mouse P2X1 receptor expressed in Xenopus oocytes assessed as reduction in ATP-induced ion current at 10 uM
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 100 uM by two electrode voltage clamping technique
Antagonist activity at mouse recombinant P2X1 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM by two electrode voltage clamping technique
Assay data:18 Tested
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