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MC1_AGON Cerep selectivity data (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as inhibition of NDP-MSH-induced intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation at 10 uM incubated for 24 hrs by beta-galactosidase reporter gene assay relative to control
Assay data:10 Tested
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
Assay data:24 Active, 2 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Partial agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay relative to control
Assay data:7 Tested
Partial agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay
Assay data:7 Active, 2 Activity ≤ 1 µM, 7 Tested
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay relative to NDP-MSH
Assay data:16 Tested
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 14 Tested
Agonist activity at mouse MC1R at 100 uM by alphascreen cAMP assay relative to NDP-MSH
Assay data:8 Tested
Agonist activity at mouse MC1R by alphascreen cAMP assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 10 Tested
Partial agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay relative to NDP-MSH
Assay data:2 Tested
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay
Assay data:13 Active, 5 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
Full agonist activity at mouse MC1R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay
Assay data:43 Active, 11 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 45 Tested
Ratio of IC50 for MDE6-82-1c to IC50 for test compound for displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method
Assay data:4 Tested
Ratio of IC50 for MDE6-82-3c to IC50 for test compound for displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method
Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method
Assay data:4 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 11 Tested
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation at 100 uM incubated for 2 hrs by cAMP Alpha-screen assay relative to control
Assay data:6 Tested
Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 3 Tested
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as fold decrease in potency of stimulation of cAMP accumulation incubated for 2 hrs by cAMP AlphaScreen assay
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation at 100 uM incubated for 2 hrs by cAMP AlphaScreen assay relative to control
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