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In vivo inhibition of human IDO1 knock-in mouse CT26 cells translated in single oral gavage dosed CD1 mouse tumor model assessed as reduction in kynurenine level in plasma measured upto 24 hrs
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vivo inhibition of human IDO1 knock-in mouse CT26 cells translated in single oral gavage dosed CD1 mouse tumor model assessed as reduction in kynurenine level in tumor measured upto 24 hrs
Protac activity at CRBN/IDO1 non-enzyme mediated p65 phosphorylation in IFNgamma-stimulated mouse GL261 cells measured at 0.1 to 10 uM after 24 hrs by Western blotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at IDO1/CRBN in IFNgamma-stimulated mouse GL261 cells assessed as IDO1 degradation by measuring decrease in intracellular protein level measured after 24 hrs by Western blotting analysis
In vivo inhibition of IDO1 in BALB/c mouse xenografted with human HCT-116 cells assessed as suppression of IDO1 mRNA expression in tumor by quantitative RT-PCR analysis
Assay data:1 Active, 2 Tested
In vivo inhibition of IDO1 in BALB/c mouse xenografted with human HCT-116 cells assessed as suppression of IDO1 expression in tumor by immunohistochemical assay
In vivo inhibition of IDO1 in CB17-SCID mouse xenografted with human SK-OV-3 cells assessed as reduction in ratio of kynurenine to tryptophan in tumor at 100 mg/kg, po measured after 6 hrs by LC-MS/MS analysis
In vivo inhibition of IDO1 in CB17-SCID mouse xenografted with human SK-OV-3 cells assessed as reduction in ratio of kynurenine to tryptophan in plasma at 100 mg/kg, po measured after 6 hrs by LC-MS/MS analysis
Assay for IDO1 Enzymatic Activity Determination from US Patent US10945994: "Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In vivo inhibition of IDO1 in plasma of NSG mouse xenografted with human SKOV3 cells at 75 mg/kg, po BID by LC-MS analysis
In vivo inhibition of IDO1 in plasma of NSG mouse xenografted with human SKOV3 cells at 125 mg/kg, po BID measured after 12 hrs by LC-MS analysis
In vivo inhibition of IDO1 in plasma of NSG mouse xenografted with human SKOV3 cells at 200 mg/kg, po BID measured after 12 hrs by LC-MS analysis
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells at 75 mg/kg, po BID by LC-MS analysis
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells at 125 mg/kg, po BID measured after 12 hrs by LC-MS analysis
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells at 200 mg/kg, po BID measured after 12 hrs by LC-MS analysis
In vivo inhibition of IDO1 in tumor of po dosed NSG mouse xenografted with human SKOV3 cells assessed as reduction in KYN level administered as single dose measured at 24 hrs post dose
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vivo inhibition of IDO1 in tumor of po dosed NSG mouse xenografted with human SKOV3 cells assessed as reduction in KYN level administered twice daily for 5 days measured at 12 hrs post dose
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells assessed as KYN level at 50 mg/kg, po QD measured at 24 hrs post dose
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells assessed as KYN level at 3 mg/kg, po QD measured at 24 hrs post dose
Assay data:2 Tested
In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells assessed as KYN level at 125 mg/kg, po QD administered for 5 days and measured at 4 hrs post dose
Assay data:3 Tested
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