Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition Assay from US Patent US11548860: "Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1"
Assay data:11 Active, 3 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of aromatase (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human placental microsome CYP19 using [1beta-3H]-androstenedione as substrate
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assay
Assay data:24 Active, 15 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as substrate incubated for 30 mins in presence of NADPH by fluorescence assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of aromatase in human placental microsomes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of aromatase in human breast tumor
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant aromatase expressed in baculovirus insect cell using 7-methoxy-trifluoromethyl coumarin (MFC) as substrate preincubated for 10 mins followed by substrate addition and measured for 30 mins by fluorescence based assay
Inhibition of human aromatase assessed as reduction in fluorescence intensity preincubated with NADPH regenerating system for 10 mins followed by substrate addition incubated for 60 mins by fluorescence based microplate reader analysis
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
CYP19 Inhibition Assay from US Patent US9271963: "Selective inhibitors of human corticosteroid synthases"
Assay data:16 Active, 6 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Aromatase Inhibition Activity Assay from Article 10.1111/cbdd.12812: "Synthesis, biological evaluation, and molecular docking studies of new pyrazol-3-one derivatives with aromatase inhibition activities."
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Aromatase Assay from Article 10.1111/j.1747-0285.2012.01439.x: "Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents."
Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Aromatase Assay from Article 10.1080/14756360400015256: "Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase."
Assay data:5 Active, 1 Activity ≤ 1 µM, 10 Tested
Enzyme Assay from Article 10.1080/14756360109162390: "Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis."
Assay data:11 Tested
Biological Assay from Article 10.1016/j.bioorg.2004.06.008: "Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors."
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
QR2 Assay and IC50 Value Determination from Article 10.1021/jm801335z: "Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities."
Assay data:14 Active, 6 Activity ≤ 1 µM, 23 Tested
Z-LYTE Enzymatic Kinase Assay from Article 10.1021/cb700200w: "Discovery of selective aminothiazole aurora kinase inhibitors."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Aromatase Inhibition Assay from Article 10.1021/jm061462b: "Dual aromatase-steroid sulfatase inhibitors."
Assay data:31 Active, 11 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Aromatase Inhibition Assay from Article 10.1021/jm800168s: "Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity."
Assay data:20 Active, 2 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested
HTRF Assay of Receptor Tyrosine Kinase from Article 10.1021/jm701096v: "3-Amino-benzo[d]isoxazoles as Novel Multitargeted Inhibitors of Receptor Tyrosine Kinases."
Assay data:37 Active, 35 Activity ≤ 1 µM, 38 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on