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Inhibition of AMPA receptor in mouse cortical neurons assessed as effect on AMPA currents
Assay data:1 Tested
SummaryRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Antagonist activity against AMPA receptor assessed as inhibition of SAMPA-induced depolarization of mouse cortex
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice
Assay data:6 Active, 61 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice
Assay data:1 Active, 61 Tested
Binding affinity towards GluR1 receptor from rat brain
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
The potency at recombinant rat AMPA-R was measured on GluR1 receptor expressed in Xenopus Laevis oocytes
SummaryPubMed CitationRelated BioAssays by Target
Effective concentration of compound was determined for electrophysiological properties on Metabotropic glutamate receptor 1 using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 using rat cortical slice model in Xenopus laevis oocytes
Assay data:1 Active, 1 Tested
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
Compound was tested for binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA as a radioligand.
Assay data:19 Active, 11 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonism at ionotropic glutamate receptor AMPA in mouse cortical wedge preparation
Compound was tested for in vitro binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA ligand
Assay data:6 Active, 5 Activity ≤ 1 µM, 8 Tested
Assay data:4 Active, 5 Tested
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