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Inhibition of GLI1 transcriptional activity in HH-responsive mouse NIH3T3 cells assessed as reduction in SAG-induced luciferase activity at 5 uM incubated for 48 hrs by luciferase reporter gene assay relative to control
Assay data:23 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GLI1 transcriptional activity in HH-responsive mouse NIH3T3 cells assessed as reduction in GLI1 protein expression at 5 uM incubated for 48 hrs in presence of SAG by Western blot analysis
Assay data:12 Active, 23 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GLI1/GLI2 in mouse Shh Light2 cells assessed as reduction in endogenous hedgehog signalling in presence of Smo agonist SAG by luciferase reporter gene assay
Assay data:2 Active, 2 Tested
Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts up to 30 uM after 24 hrs by renilla luciferase reporter gene assay
Assay data:1 Tested
Inhibition of Gli1 transcriptional activity in Smo-/- mouse embroyonic fibroblasts up to 20 uM after 24 hrs by renilla luciferase reporter gene assay
Assay data:2 Active, 4 Tested
Inhibition of Gli1 transcriptional activity in mouse embroyonic fibroblasts after 24 hrs by renilla luciferase reporter gene assay
Assay data:1 Active, 16 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Single concentration confirmation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay
Assay data:482 Active, 2464 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay
Assay data:786 Active, 2464 Tested
SAR analysis of small molecule antagonists of Gli-SUFU in a luminescent reporter assay - Set 2
Assay data:5 Active, 4 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis of small molecule antagonists of Gli-SUFU in a luminescent reporter assay - Set 1
Assay data:10 Active, 8 Activity ≤ 1 µM, 60 Tested
Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
Assay data:309 Active, 15 Activity ≤ 1 µM, 344 Tested
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
Assay data:979 Active, 2464 Tested
Summary assay for small molecule Antagonists of Gli-Sufu Antagonists
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay
Assay data:2509 Active, 338560 Tested
Inhibition of GLI1 induced hedgehog signaling in mouse NIH3T3 cells
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