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Inhibition of [125I]RTI-55 binding to mouse DAT expressed in HEK293 cells preincubated for 10 mins followed by radioligand addition measured after 90 mins by micro beta scintillation counting analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse DAT expressed in HEK293 cells assessed as reduction in [3H]-DA uptake
Assay data:7 Active, 3 Activity ≤ 1 µM, 7 Tested
Enhancing of [125I]RTI-55 binding to mouse DAT expressed in HEK293 cells preincubated for 10 mins followed by radioligand addition measured after 90 mins by micro beta scintillation counting analysis
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Displacement of [3H]RTI-121 from mouse DAT in striatal membranes
Assay data:11 Active, 5 Activity ≤ 1 µM, 12 Tested
Displacement of [3H]RTI-121 from mouse DAT in striatal membranes at 10000 nM
Assay data:13 Tested
SummaryPubMed CitationRelated BioAssays by Target
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Displacement of [3H]WIN-35428 from DAT in mouse brain
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Tested in vitro for dopamine(DA) neuronal uptake inhibition
Assay data:24 Active, 1 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 27 Tested
Inhibitory activity against Haloperidol catalepsy in mice (sc)
Assay data:28 Tested
Compound was evaluated for the inhibitory activity against Haloperidol catalepsy in mice
Assay data:3 Tested
post-synaptic dopamine autoreceptor antagonist activity evaluated by inhibition of the apomorphine-induced stereotyped behavior in mice.
Assay data:31 Tested
In vivo potentiation of compound towards Dopamine transporter after po administration was determined in mouse using mouse locomotor activity hypothermia; ND=not determined
Assay data:1 Tested
In vivo potentiation of compound towards Dopamine transporter after po administration was determined in mouse using mouse locomotor activity hypothermia
Assay data:2 Tested
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