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Invivo induction of BTK degradation in human OCILY10 cells xenografted in SCID mouse assessed as decrease in BTK level in tumor at 10 mg/kg, po administered once daily for 17 days by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Invivo induction of BTK degradation in ICR mouse monocytes assessed as protein remaining at 100 mg/kg, po after 6 hrs by Western blot analysis relative to control
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Invivo induction of BTK degradation in ICR mouse monocytes at 20 mg/kg, po after 24 hrs by Western blot analysis relative to control
Assay data:2 Tested
Invivo induction of BTK degradation in ICR mouse monocytes assessed as protein remaining at 100 mg/kg, po after 24 hrs by Western blot analysis relative to control
Invivo induction of BTK degradation in human OCILY10 cells xenografted in SCID mouse assessed as decrease in BTK level in tumor administered orally twice daily for 17 days by Western blot analysis
Invivo induction of BTK degradation in ICR mouse monocytes at 20 mg/kg, po after 8 hrs by Western blot analysis relative to control
In vivo inhibition of autophosphorylation of BTK at Y223 in mouse at 7.5 to 30 mg/kg, po measured up to 8 hrs by Western blot analysis
Inhibition of BTK in BABL/c mouse blood assessed as reduction in BTK phosphorylation at Tyr223 residue at 30 mg/kg, po measured after 8 hrs
Inhibition of BTK in BABL/c mouse blood assessed as reduction in BTK phosphorylation at Tyr223 residue at 15 mg/kg, po measured after 8 hrs
Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulation and measured after overnight by flow cytometry analysis
Assay data:10 Active, 10 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BTK in DBA1 mouse whole blood assessed as reduction in BTK phosphorylation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of mouse BTK expressed in baculovirus infected Sf21 cells incubated for 1 hr by Western blot analysis
Inhibition of BTK in mouse whole blood assessed as reduction in anti-IgM/IgG-induced CD69 surface expression on peripheral B cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 1.5 mg/kg, po qd administered via gavage measured after 24 hrs relative to control
In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 0.5 mg/kg, po qd administered via gavage measured after 24 hrs relative to control
In-vivo inhibition of BTK in NZB/WF1 mouse model of lupus prone at 0.2 mg/kg, po qd administered via gavage measured after 24 hrs relative to control
In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 2.5 mg/kg, po qd after 24 hrs relative to control
In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 0.5 mg/kg, po qd after 24 hrs relative to control
In-vivo inhibition of BTK in DBA1/J mouse model of collagen-induced arthritis at 0.1 mg/kg, po qd after 24 hrs relative to control
In-vivo inhibition of BTK in BALB/c mouse at 0.5 to 2.5 mg/kg, po single dose after 48 hrs relative to control
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