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Inhibition of Cyclophilin D in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) induced decrease in cell viability at 5 uM after 24 hrs by MTT assay relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Cyclophilin D in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) induced reactive oxygen species production at 5 uM after 6 hrs by CMH2DCFDA dye based fluorescence assay relative to control
Inhibition of Cyclophilin D in mouse HT22 cells assessed as neuroprotective activity against amyloid beta (1 to 42) induced impairment of ATP production by measuring assessed as recovery of ATP production at 5 uM pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation measured after 7 hrs by luciferase based assay relative to control
Assay data:9 Tested
Inhibition of Cyclophilin D in mouse HT22 cells assessed as neuroprotective activity against amyloid beta (1 to 42) induced impairment of ATP production by measuring cell viability at 5 pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation measured after 7 hrs by luciferase based assay relative to control
Inhibition of cyclophilin D in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) induced mitochondrial permeability transition pore opening by measuring increase in green to red fluorescence ratio at 5 uM pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation measured at 1 hr interval for 3 hrs by JC-1 dye based fluorescence assay relative to control
Assay data:26 Tested
Blockade of amyloid beta (1 to 42)-induced cypD-mediated mPTP opening in mouse HT22 cells assessed as green to red fluorescence ratio at 5 uM preincubated for 10 mins followed by amyloid beta (1 to 42) addition measured at 1 hr time interval for 3 hrs by JC-1 staining based fluorescence assay (Rvb = 100%)
Assay data:29 Tested
Inhibition of cyclophilin D in mouse brain cortical mitochondria assessed as suppression of calcium-induced mitochondrial swelling at 5 uM incubated for 5 mins by spectrophotometric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of cyclophilin D in mouse brain cortical mitochondria assessed as suppression of calcium-induced mitochondrial swelling incubated for 5 mins by spectrophotometric analysis
Assay data:1 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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