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PAK4 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
PAK4 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of PAK4 (unknown origin)
Assay data:3 Tested
Thermal Shift Assay. Domain: start/stop: S291-R591
Assay data:27 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for 3 hrs by ELISA
Binding affinity to human PAK4 (300 to 591 residues) assessed as dissociation constant by isothermal calorimetric analysis
Inhibition of human PAK4 assessed as inhibition constant
Inhibition of PAK4 phosphorylation at Ser474 residue in human MV4-11 cells at 50 to 800 nM incubated for 24 hrs by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human PAK4 assessed as enzymatic activity at 2 uM incubated for 20 mins by filter binding method relative to control
Assay data:12 Tested
Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding method
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Inhibition of PAK4 (unknown origin) at 1.0 uM relative to control
Inhibition of PAK4 (unknown origin) at 1 uM relative to control
Inhibition of human PAK4 (2 to 591 residues) expressed in Escherichia coli expression system at 1 uM using RRRLSFAEPG peptide as substrate incubated for 30 mins in presence of [gamma33P]ATP by scintillation based radioactive filter binding assay relative to control
Inhibition of PAK4 (unknown origin) using S2 as substrate incubated for 60 mins in the presence of ATP by time-resolved HTRF assay
Inhibition of PAK4 (unknown origin) incubated for 60 mins by time-resolved HTRF assay
Assay data:19 Active, 10 Activity ≤ 1 µM, 26 Tested
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