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Antagonistic activity at NAADP receptor in sea urchin egg homogenate assessed as inhibition of NAADP-mediated Ca2+ release using Fluo-3 staining based fluorimetric assay relative to control
Assay data:6 Active, 2 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [32P]NAADP from NAADP receptor in sea urchin egg homogenate preincubated 10 mins before [32P]NAADP addition
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [32P]NAADP from Egg-binding protein in sea urchin egg homogenate at 6 uM after 10 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of SERCA in sea urchin eggs assessed as Ca2+ leak rate at 10 uM relative to thapsigargin
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at ryanodine receptor in sea urchin egg homogenates assessed as decrease in cADPcR-induced calcium release by fluorimetry
Assay data:4 Tested
SummaryPubMed Citation
Agonist activity at ryanodine receptor in sea urchin egg homogenates assessed as effect on calcium release by fluorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at cADPR receptor in sea urchin egg homogenates assessed as inhibition of calcium release
Concentration response relationship was used to measure half-maximally effective agonist concentration.
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Antagonistic activity at NAADP receptor in intact sea urchin eggs assessed as Inhibition of NAADP mediated Ca2+ increase at 100 uM using Oregon Green 488-BAPTA Dextran staining based by laser scanning confocal microscopy
Displacement of [32P]NAADP from NAADP receptor in sea urchin egg homogenate after 5 days
Noncompetitive inhibition of NAADP receptor in sea urchin egg homogenate assessed as inhibition of NAADP induced Ca2+ release using Fluo-3 staining based fluorimetric assay
Agonist activity at ryanodine receptor in sea urchin egg homogenates assessed as effect on calcium release at 30 uM by fluorimetry
Inhibition of SERCA in sea urchin eggs assessed as Ca2+ leak rate at 10 uM
Assay data:1 Tested
Inhibition of SERCA in sea urchin eggs assessed as Ca2+ leak rate
Inhibition of sea urchin egg division
Agonist activity at human cADPR receptor in intact sea urchin egg assessed as stimulation of calcium release
Agonist activity at human cADPR receptor in sea urchin egg homogenates assessed as stimulation of calcium release
Assay data:1 Active, 3 Tested
Maximal Ca+ release response was determined from Sea urchin (Lytechinus pictus eggs) homogenate assay
Assay data:3 Tested
Concentration response relationship was fitted to logistic equations using kaleidagraph software from which maximal response was measured.
[Ca2+] release with 10 uM was measured by non-specific binding method.
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