Alternative titles; symbols
HGNC Approved Gene Symbol: FOXB2
Cytogenetic location: 9q21.2 Genomic coordinates (GRCh38): 9:77,019,655-77,020,953 (from NCBI)
FOXB2 is a winged helix gene (Kaestner et al., 1996).
Kaestner et al. (1993) cloned mouse Foxb2, also known as Fkh4, which shares a high degree of similarity with the Drosophila forkhead gene. Fkh4 was expressed during mouse embryogenesis and in adult brain, thymus, spleen, ovary, and testis.
Kaestner et al. (1996) cloned the cDNA of mouse Fkh4, which encodes a 427-amino acid protein with a calculated molecular mass of 45.2 kD. Fkh4 contains a class IV winged helix domain; from the N terminus to the winged helix domain is a very short domain of only 10 amino acids. The C-terminal domain of the Fkh4 protein contains stretches of histidines and alanines. RNase protection analysis detected expression of Fkh4 in only hypothalamus of adult mouse brain. In situ hybridization of mouse embryos indicated expression of Fkh4 in the developing diencephalon from the headfold stage onward.
Kaestner et al. (1996) determined that mouse Fkh4 gene consists of 1 exon.
Gross (2022) mapped the FOXB2 gene to chromosome 9q21.2 based on an alignment of the FOXB2 sequence (GenBank NM_001013735) with the genomic sequence (GRCh38).
Using linkage analysis, Kaestner et al. (1996) mapped the Fkh4 gene to mouse chromosome 19.
Gross, M. B. Personal Communication. Baltimore, Md. 8/9/2022.
Kaestner, K. H., Lee, K. H., Schlondorff, J., Hiemisch, H., Monaghan, A. P., Schutz, G. Six members of the mouse forkhead gene family are developmentally regulated. Proc. Nat. Acad. Sci. 90: 7628-7631, 1993. [PubMed: 7689224] [Full Text: https://doi.org/10.1073/pnas.90.16.7628]
Kaestner, K. H., Schutz, G., Monaghan, A. P. Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system. Mech. Dev. 55: 221-230, 1996. [PubMed: 8861101] [Full Text: https://doi.org/10.1016/0925-4773(96)00507-2]