Entry - *615580 - ZINC FINGER PROTEIN 528; ZNF528 - OMIM

 
 
* 615580

ZINC FINGER PROTEIN 528; ZNF528


Alternative titles; symbols

KIAA1827


HGNC Approved Gene Symbol: ZNF528

Cytogenetic location: 19q13.41     Genomic coordinates (GRCh38): 19:52,397,849-52,418,401 (from NCBI)


TEXT

▼ Cloning and Expression

By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2001) cloned ZNF528, which they designated KIAA1827. The transcript contains repetitive elements in its 3-prime UTR. The deduced 469-amino acid protein shares 57% and 61% identity with human ZNF91 (603971) and ZNF83 (194558), respectively. RT-PCR ELISA detected ZNF528 expression in all adult and fetal tissues and specific adult brain regions examined. Highest expression was detected in adult cerebellum and caudate nucleus, and lowest expression was detected in adult liver. Database analysis revealed a related transcription factor in Drosophila.


▼ Mapping

Hartz (2013) mapped the ZNF528 gene to chromosome 19q13.41 based on an alignment of the ZNF528 sequence (GenBank AB058730) with the genomic sequence (GRCh37).

▼ REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 12/20/2013.

  2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001. [PubMed: 11347906, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 12/20/2013
Edit History:
carol : 01/10/2014
mgross : 1/2/2014
mgross : 12/20/2013
mgross : 12/20/2013
mcolton : 12/20/2013

* 615580

ZINC FINGER PROTEIN 528; ZNF528


Alternative titles; symbols

KIAA1827


HGNC Approved Gene Symbol: ZNF528

Cytogenetic location: 19q13.41     Genomic coordinates (GRCh38): 19:52,397,849-52,418,401 (from NCBI)


TEXT

Cloning and Expression

By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2001) cloned ZNF528, which they designated KIAA1827. The transcript contains repetitive elements in its 3-prime UTR. The deduced 469-amino acid protein shares 57% and 61% identity with human ZNF91 (603971) and ZNF83 (194558), respectively. RT-PCR ELISA detected ZNF528 expression in all adult and fetal tissues and specific adult brain regions examined. Highest expression was detected in adult cerebellum and caudate nucleus, and lowest expression was detected in adult liver. Database analysis revealed a related transcription factor in Drosophila.


Mapping

Hartz (2013) mapped the ZNF528 gene to chromosome 19q13.41 based on an alignment of the ZNF528 sequence (GenBank AB058730) with the genomic sequence (GRCh37).

REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 12/20/2013.

  2. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 8: 85-95, 2001. [PubMed: 11347906] [Full Text: https://doi.org/10.1093/dnares/8.2.85]


Creation Date:
Patricia A. Hartz : 12/20/2013

Edit History:
carol : 01/10/2014
mgross : 1/2/2014
mgross : 12/20/2013
mgross : 12/20/2013
mcolton : 12/20/2013



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 17, 2024