Entry - *615069 - H4 HISTONE 16; H4-16 - OMIM

 
 
* 615069

H4 HISTONE 16; H4-16


Alternative titles; symbols

HISTONE GENE CLUSTER 4, H4 HISTONE; HIST4H4
HISTONE GENE CLUSTER 4, H4
HIST4 CLUSTER, H4
H4/P


HGNC Approved Gene Symbol: H4C16

Cytogenetic location: 12p12.3     Genomic coordinates (GRCh38): 12:14,770,720-14,771,131 (from NCBI)


▼ TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

▼ Cloning and Expression

Using PCR, Marzluff et al. (2002) cloned human HIST4H4. All mouse and human H4 genes, including HIST4H4, encode the same protein. The HIST4H4 mRNA ends in a conserved stem loop found in replication-dependent histones. An S1 nuclease protection assay showed that HIST4H4 was expressed in human U2OS and 293T cell lines.


▼ Mapping

By genomic sequence analysis, Marzluff et al. (2002) mapped the HIST4H4 gene to chromosome 12p13.1. They mapped the mouse ortholog to a syntenic region on chromosome 6G1.


▼ Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

▼ REFERENCES

  1. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966, related citations]


Creation Date:
Matthew B. Gross : 2/7/2013
Edit History:
mgross : 04/21/2022
mgross : 02/07/2013

* 615069

H4 HISTONE 16; H4-16


Alternative titles; symbols

HISTONE GENE CLUSTER 4, H4 HISTONE; HIST4H4
HISTONE GENE CLUSTER 4, H4
HIST4 CLUSTER, H4
H4/P


HGNC Approved Gene Symbol: H4C16

Cytogenetic location: 12p12.3     Genomic coordinates (GRCh38): 12:14,770,720-14,771,131 (from NCBI)


TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

Cloning and Expression

Using PCR, Marzluff et al. (2002) cloned human HIST4H4. All mouse and human H4 genes, including HIST4H4, encode the same protein. The HIST4H4 mRNA ends in a conserved stem loop found in replication-dependent histones. An S1 nuclease protection assay showed that HIST4H4 was expressed in human U2OS and 293T cell lines.


Mapping

By genomic sequence analysis, Marzluff et al. (2002) mapped the HIST4H4 gene to chromosome 12p13.1. They mapped the mouse ortholog to a syntenic region on chromosome 6G1.


Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

REFERENCES

  1. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966]


Creation Date:
Matthew B. Gross : 2/7/2013

Edit History:
mgross : 04/21/2022
mgross : 02/07/2013



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 14, 2024