HGNC Approved Gene Symbol: THAP8
Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,034,984-36,054,762 (from NCBI)
By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP8. The THAP domain of the deduced 274-amino acid THAP8 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.
Hartz (2009) mapped the THAP8 gene to chromosome 19q13.12 based on an alignment of the THAP8 sequence (GenBank AK057453) with the genomic sequence (build 36.1).
Hartz, P. A. Personal Communication. Baltimore, Md. 1/16/2009.
Roussigne, M., Kossida, S., Lavigne, A.-C., Clouaire, T., Ecochard, V., Glories, A., Amalric, F., Girard, J.-P. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 28: 66-69, 2003. [PubMed: 12575992] [Full Text: https://doi.org/10.1016/S0968-0004(02)00013-0]