Entry - *612533 - THAP DOMAIN-CONTAINING PROTEIN 4; THAP4 - OMIM

 
 
* 612533

THAP DOMAIN-CONTAINING PROTEIN 4; THAP4


HGNC Approved Gene Symbol: THAP4

Cytogenetic location: 2q37.3     Genomic coordinates (GRCh38): 2:241,584,405-241,637,576 (from NCBI)


TEXT

▼ Cloning and Expression

By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP4. The THAP domain of the deduced 577-amino acid THAP4 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.


▼ Mapping

Hartz (2009) mapped the THAP4 gene to chromosome 2q37.3 based on an alignment of the THAP4 sequence (GenBank AF132970) with the genomic sequence (build 36.1).

▼ REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/16/2009.

  2. Roussigne, M., Kossida, S., Lavigne, A.-C., Clouaire, T., Ecochard, V., Glories, A., Amalric, F., Girard, J.-P. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 28: 66-69, 2003. [PubMed: 12575992, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 1/16/2009
Edit History:
mgross : 01/16/2009

* 612533

THAP DOMAIN-CONTAINING PROTEIN 4; THAP4


HGNC Approved Gene Symbol: THAP4

Cytogenetic location: 2q37.3     Genomic coordinates (GRCh38): 2:241,584,405-241,637,576 (from NCBI)


TEXT

Cloning and Expression

By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP4. The THAP domain of the deduced 577-amino acid THAP4 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.


Mapping

Hartz (2009) mapped the THAP4 gene to chromosome 2q37.3 based on an alignment of the THAP4 sequence (GenBank AF132970) with the genomic sequence (build 36.1).

REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/16/2009.

  2. Roussigne, M., Kossida, S., Lavigne, A.-C., Clouaire, T., Ecochard, V., Glories, A., Amalric, F., Girard, J.-P. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 28: 66-69, 2003. [PubMed: 12575992] [Full Text: https://doi.org/10.1016/S0968-0004(02)00013-0]


Creation Date:
Patricia A. Hartz : 1/16/2009

Edit History:
mgross : 01/16/2009



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 29, 2024