HGNC Approved Gene Symbol: THAP3
Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,624,868-6,635,595 (from NCBI)
By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP3. The THAP domain of the deduced 239-amino acid THAP3 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.
Bessiere et al. (2008) found that, although the THAP domains of THAP1 (609520) and THAP3 are similar, the zinc finger within the THAP domain of THAP3 did not bind DNA containing a consensus THAP1-binding element.
Hartz (2009) mapped the THAP3 gene to chromosome 1p36.31 based on an alignment of the THAP3 sequence (GenBank AF086370) with the genomic sequence (build 36.1).
Bessiere, D., Lacroix, C., Campagne, S., Ecochard, V., Guillet, V., Mourey, L., Lopez, F., Czaplicki, J., Demange, P., Milon, A., Girard, J.-P., Gervais, V. Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways. J. Biol. Chem. 283: 4352-4363, 2008. [PubMed: 18073205] [Full Text: https://doi.org/10.1074/jbc.M707537200]
Hartz, P. A. Personal Communication. Baltimore, Md. 1/16/2009.
Roussigne, M., Kossida, S., Lavigne, A.-C., Clouaire, T., Ecochard, V., Glories, A., Amalric, F., Girard, J.-P. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 28: 66-69, 2003. [PubMed: 12575992] [Full Text: https://doi.org/10.1016/S0968-0004(02)00013-0]