HGNC Approved Gene Symbol: THAP2
Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,664,301-71,680,644 (from NCBI)
By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP2. The THAP domain of the deduced 228-amino acid THAP2 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids.
Bessiere et al. (2008) found that the zinc finger within the THAP domain of THAP2 had the same 3-dimensional fold as that of THAP1 (609520), which includes a characteristic loop-helix-loop motif. However, THAP2 did not bind DNA containing a consensus THAP1-binding element.
Hartz (2009) mapped the THAP2 gene to chromosome 12q21.1 based on an alignment of the THAP2 sequence (GenBank BC0083528) with the genomic sequence (build 36.1).
Bessiere, D., Lacroix, C., Campagne, S., Ecochard, V., Guillet, V., Mourey, L., Lopez, F., Czaplicki, J., Demange, P., Milon, A., Girard, J.-P., Gervais, V. Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways. J. Biol. Chem. 283: 4352-4363, 2008. [PubMed: 18073205] [Full Text: https://doi.org/10.1074/jbc.M707537200]
Hartz, P. A. Personal Communication. Baltimore, Md. 1/16/2009.
Roussigne, M., Kossida, S., Lavigne, A.-C., Clouaire, T., Ecochard, V., Glories, A., Amalric, F., Girard, J.-P. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 28: 66-69, 2003. [PubMed: 12575992] [Full Text: https://doi.org/10.1016/S0968-0004(02)00013-0]