Alternative titles; symbols
HGNC Approved Gene Symbol: CISD3
Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,730,341-38,735,605 (from NCBI)
CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007).
By database analysis using CISD1 (611932) as query, Wiley et al., 2007 identified CISD3, which they called MINER2. The deduced 126-amino acid protein contains 2 C-terminal CDGSH domains. Immunofluorescence localized CISD3 to the mitochondria. They noted that purified recombinant CISD3 was strikingly red in color. Wiley et al., 2007 showed that the CDGSH domain of CISD1 harbors a redox-sensitive 2Fe-2S cluster and suggested that the CDGSH domains of CISD3 likewise bind 2Fe-2S and have similar biophysical properties.
Gross (2018) mapped the CISD3 gene to chromosome 17q12 based on an alignment of the CISD3 sequence (GenBank NM_001136498) with the genomic sequence (GRCh38).
Gross, M. B. Personal Communication. Baltimore, Md. 2/5/2018.
Wiley, S. E., Murphy, A. N., Ross, S. A., van der Geer, P., Dixon, J. E. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc. Nat. Acad. Sci. 104: 5318-5323, 2007. [PubMed: 17376863] [Full Text: https://doi.org/10.1073/pnas.0701078104]
Wiley, S. E., Paddock, M. L., Abresch, E. C., Gross, L., van der Geer, P., Nechushtai, R., Murphy, A. N., Jennings, P. A., Dixon, J. E. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J. Biol. Chem. 282: 23745-23749, 2007. [PubMed: 17584744] [Full Text: https://doi.org/10.1074/jbc.C700107200]