Entry - *611872 - REGULATOR OF MICROTUBULE DYNAMICS 2; RMDN2 - OMIM

 
 
* 611872

REGULATOR OF MICROTUBULE DYNAMICS 2; RMDN2


Alternative titles; symbols

RMD2
FAMILY WITH SEQUENCE SIMILARITY 82, MEMBER A1; FAM82A1
FAMILY WITH SEQUENCE SIMILARITY 82, MEMBER A, FORMERLY; FAM82A, FORMERLY


HGNC Approved Gene Symbol: RMDN2

Cytogenetic location: 2p22.2     Genomic coordinates (GRCh38): 2:37,920,901-38,067,138 (from NCBI)


TEXT

▼ Cloning and Expression

By database searching, Oishi et al. (2007) identified 3 human proteins related to a family of microtubule-associated proteins in C. elegans: RMD1 (FAM82B; 611871), RMD2, and RMD3 (FAM82C; 611873). The deduced proteins in both species contain multiple coiled-coil domains and localize to spindle microtubules and spindle poles during cell division. In interphase, the human RMD proteins localized to the cytoplasm, with some staining in the microtubule lattice. RMD2 was also observed in the perinuclear region.


▼ Gene Function

Using cosedimentation assays, Oishi et al. (2007) showed that human RMD1, RMD2, and RMD3 proteins interact with microtubules.


▼ Mapping

Scott (2008) mapped the FAM82A gene to chromosome 2p22.2 based on an alignment of the FAM82A sequence (GenBank AC009229) with the genomic sequence (build 36.2).

▼ REFERENCES

  1. Oishi, K., Okano, H., Sawa H. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J. Cell Biol. 179: 1149-1162, 2007. Note: Erratum: J. Cell Biol. 186: 629 only, 2009. [PubMed: 18070910, images, related citations] [Full Text]

  2. Scott, A. F. Personal Communication. Baltimore, Md. 2/14/2008.


Creation Date:
Alan F. Scott : 3/3/2008
Edit History:
carol : 11/01/2022
carol : 08/21/2012
mgross : 9/23/2008
carol : 3/3/2008

* 611872

REGULATOR OF MICROTUBULE DYNAMICS 2; RMDN2


Alternative titles; symbols

RMD2
FAMILY WITH SEQUENCE SIMILARITY 82, MEMBER A1; FAM82A1
FAMILY WITH SEQUENCE SIMILARITY 82, MEMBER A, FORMERLY; FAM82A, FORMERLY


HGNC Approved Gene Symbol: RMDN2

Cytogenetic location: 2p22.2     Genomic coordinates (GRCh38): 2:37,920,901-38,067,138 (from NCBI)


TEXT

Cloning and Expression

By database searching, Oishi et al. (2007) identified 3 human proteins related to a family of microtubule-associated proteins in C. elegans: RMD1 (FAM82B; 611871), RMD2, and RMD3 (FAM82C; 611873). The deduced proteins in both species contain multiple coiled-coil domains and localize to spindle microtubules and spindle poles during cell division. In interphase, the human RMD proteins localized to the cytoplasm, with some staining in the microtubule lattice. RMD2 was also observed in the perinuclear region.


Gene Function

Using cosedimentation assays, Oishi et al. (2007) showed that human RMD1, RMD2, and RMD3 proteins interact with microtubules.


Mapping

Scott (2008) mapped the FAM82A gene to chromosome 2p22.2 based on an alignment of the FAM82A sequence (GenBank AC009229) with the genomic sequence (build 36.2).

REFERENCES

  1. Oishi, K., Okano, H., Sawa H. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J. Cell Biol. 179: 1149-1162, 2007. Note: Erratum: J. Cell Biol. 186: 629 only, 2009. [PubMed: 18070910] [Full Text: https://doi.org/10.1083/jcb.200705108]

  2. Scott, A. F. Personal Communication. Baltimore, Md. 2/14/2008.


Creation Date:
Alan F. Scott : 3/3/2008

Edit History:
carol : 11/01/2022
carol : 08/21/2012
mgross : 9/23/2008
carol : 3/3/2008



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 10, 2024