Alternative titles; symbols
HGNC Approved Gene Symbol: SLC22A20P
Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,213,840-65,242,757 (from NCBI)
SLC22A20 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007).
By searching a human database for SLC22 family members, Jacobsson et al. (2007) identified SLC22A20. The deduced 573-amino acid protein has 12 putative transmembrane domains. Quantitative real-time PCR detected high expression of rat Slc22a20 in coronal sections taken through the olfactory bulb and forebrain. Expression was much weaker in other coronal sections and in liver and adipose tissue, and was not detected in other brain regions or in peripheral tissues.
Jacobsson et al. (2007) determined that the SLC22A20 gene contains 9 exons.
Jacobsson et al. (2007) stated that the SLC22A20 gene maps to chromosome 11q13.1; the mouse Slc22a20 gene maps to chromosome 19qA.
Jacobsson, J. A., Haitina, T., Lindblom, J., Fredriksson, R. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics 90: 595-609, 2007. [PubMed: 17714910] [Full Text: https://doi.org/10.1016/j.ygeno.2007.03.017]