Entry - *609792 - LEUCINE-RICH REPEAT- AND Ig DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3; LINGO3 - OMIM

 
 
* 609792

LEUCINE-RICH REPEAT- AND Ig DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3; LINGO3


Alternative titles; symbols

LEUCINE-RICH REPEAT PROTEIN, NEURONAL, 6B; LRRN6B
LEUCINE-RICH REPEAT NEURONAL PROTEIN 2; LERN2


HGNC Approved Gene Symbol: LINGO3

Cytogenetic location: 19p13.3     Genomic coordinates (GRCh38): 19:2,287,164-2,308,154 (from NCBI)


TEXT

▼ Cloning and Expression

By searching databases for genes similar to LRRN6A (LINGO1; 609791), Carim-Todd et al. (2003) identified LRRN6B. The deduced 647-amino acid protein, which they designated LERN2, has an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, a C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail. It shares 53% amino acid identity with LRRN6A.


▼ Mapping

By genomic sequence analysis, Carim-Todd et al. (2003) mapped the LRRN6B gene to chromosome 19.


▼ REFERENCES

  1. Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Europ. J. Neurosci. 18: 3167-3182, 2003. [PubMed: 14686891, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 12/15/2005
Edit History:
carol : 08/29/2018
mgross : 12/15/2005
mgross : 12/15/2005

* 609792

LEUCINE-RICH REPEAT- AND Ig DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3; LINGO3


Alternative titles; symbols

LEUCINE-RICH REPEAT PROTEIN, NEURONAL, 6B; LRRN6B
LEUCINE-RICH REPEAT NEURONAL PROTEIN 2; LERN2


HGNC Approved Gene Symbol: LINGO3

Cytogenetic location: 19p13.3     Genomic coordinates (GRCh38): 19:2,287,164-2,308,154 (from NCBI)


TEXT

Cloning and Expression

By searching databases for genes similar to LRRN6A (LINGO1; 609791), Carim-Todd et al. (2003) identified LRRN6B. The deduced 647-amino acid protein, which they designated LERN2, has an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, a C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail. It shares 53% amino acid identity with LRRN6A.


Mapping

By genomic sequence analysis, Carim-Todd et al. (2003) mapped the LRRN6B gene to chromosome 19.


REFERENCES

  1. Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Europ. J. Neurosci. 18: 3167-3182, 2003. [PubMed: 14686891] [Full Text: https://doi.org/10.1111/j.1460-9568.2003.03003.x]


Creation Date:
Patricia A. Hartz : 12/15/2005

Edit History:
carol : 08/29/2018
mgross : 12/15/2005
mgross : 12/15/2005



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 2, 2024