Alternative titles; symbols
HGNC Approved Gene Symbol: LRIG3
Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:58,872,155-58,920,504 (from NCBI)
By searching databases for sequences similar to LRIG1 (608868) and LRIG2 (608869), followed by PCR of a human brain cDNA library, Guo et al. (2004) cloned LRIG3. The deduced 1,119-amino acid protein contains a signal peptide; 15 tandem leucine-rich repeats with cysteine-rich N- and C-flanking domains; 3 C2-type immunoglobulin-like domains; a transmembrane domain; and a cytoplasmic tail. LRIG3 shares 46.8% and 54.0% amino acid identity with LRIG1 and LRIG2, respectively, with highest conservation in the extracellular, transmembrane, and membrane-proximal sequences. Guo et al. (2004) also cloned mouse Lrig3, which shares 85.5% amino acid identity with human LRIG3. Northern blot analysis detected a 5.1-kb LRIG3 transcript in all tissues analyzed. Quantitative RT-PCR detected highest expression in stomach and lowest expression in blood. Quantitative RT-PCR of mouse tissues revealed ubiquitous expression, but the pattern of expression differed from that in human tissues.
By aligning the LRIG3 sequence (GenBank AY505340) with the genomic sequence, Hartz (2004) determined that the LRIG3 gene contains 19 exons. Guo et al. (2004) determined that the first 17 exons of mouse and human LRIG3 share the same exon/intron structure.
By genomic sequence analysis, Guo et al. (2004) mapped the LRIG3 gene to chromosome 12q13.2. They mapped the mouse Lrig3 gene to a region of chromosome 10D2 that shows homology of synteny to human chromosome 12q13.2.
Guo, D., Holmlund, C., Henriksson, R., Hedman, H. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. Genomics 84: 157-165, 2004. [PubMed: 15203213] [Full Text: https://doi.org/10.1016/j.ygeno.2004.01.013]
Hartz, P. A. Personal Communication. Baltimore, Md. 8/24/2004.