Entry - *607232 - MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY, MEMBER E; MRGPRE - OMIM

 
 
* 607232

MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY, MEMBER E; MRGPRE


Alternative titles; symbols

MRGE


HGNC Approved Gene Symbol: MRGPRE

Cytogenetic location: 11p15.4     Genomic coordinates (GRCh38): 11:3,225,030-3,232,417 (from NCBI)


TEXT

▼ Cloning and Expression

Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene (165180), including MRGE. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF (see 604643), which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.


▼ Mapping

By genomic sequence analysis, Dong et al. (2001) mapped the MRGE gene to chromosome 11.


▼ REFERENCES

  1. Dong, X., Han, S., Zylka, M. J., Simon, M. I., Anderson, D. J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-632, 2001. [PubMed: 11551509, related citations] [Full Text]


Creation Date:
Stylianos E. Antonarakis : 9/17/2002
Edit History:
mgross : 03/24/2009
mgross : 9/17/2002

* 607232

MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY, MEMBER E; MRGPRE


Alternative titles; symbols

MRGE


HGNC Approved Gene Symbol: MRGPRE

Cytogenetic location: 11p15.4     Genomic coordinates (GRCh38): 11:3,225,030-3,232,417 (from NCBI)


TEXT

Cloning and Expression

Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene (165180), including MRGE. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF (see 604643), which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.


Mapping

By genomic sequence analysis, Dong et al. (2001) mapped the MRGE gene to chromosome 11.


REFERENCES

  1. Dong, X., Han, S., Zylka, M. J., Simon, M. I., Anderson, D. J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-632, 2001. [PubMed: 11551509] [Full Text: https://doi.org/10.1016/s0092-8674(01)00483-4]


Creation Date:
Stylianos E. Antonarakis : 9/17/2002

Edit History:
mgross : 03/24/2009
mgross : 9/17/2002



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 3, 2024