HGNC Approved Gene Symbol: TACC2
Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:121,989,163-122,254,542 (from NCBI)
For background information on the TACC proteins, see TACC1 (605301).
By searching an EST database with TACC1 as the probe, Still et al. (1999) identified cDNAs encoding TACC2 and TACC3 (605303). The coiled-coil region of the 652-amino acid TACC2 protein is highly related to that of TACC1, suggesting that TACC2 arose through gene duplication.
Still et al. (1999) determined that the TACC2 gene colocalizes with the FGFR2 gene (176943) in 10q26, a region that is amplified in breast cancer and is therefore analogous to the 8p11 amplicon that contains the FGFR1 (136350) and TACC1 genes. This finding further supported the inference that TACC2 arose through gene duplication.
Schuendeln et al. (2004) generated mice lacking Tacc2. Homozygous mutant mice were viable, developed normally, were fertile, and showed no increase in tumor development. In Tacc2-deficient embryonic fibroblasts, proliferation, cell cycle progression, and centrosome numbers were comparable to those in wildtype cells. Schuendeln et al. (2004) concluded that Tacc2 is not required for mouse development and normal cell proliferation and that Tacc2 is not a tumor suppressor protein.
Schuendeln, M. M., Piekorz, R. P., Wichmann, C., Lee, Y. McKinnon, P. J., Boyd, K., Takahashi, Y., Ihle, J. N. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Molec. Cell. Biol. 24: 6403-6409, 2004. [PubMed: 15226440] [Full Text: https://doi.org/10.1128/MCB.24.14.6403-6409.2004]
Still, I. H., Hamilton, M., Vince, P., Wolfman, A., Cowell, J. K. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Oncogene 18: 4032-4038, 1999. [PubMed: 10435627] [Full Text: https://doi.org/10.1038/sj.onc.1202801]