Entry - *605157 - p53-RESPONSIVE GENE 1 - OMIM

 
 
* 605157

p53-RESPONSIVE GENE 1


Alternative titles; symbols

PRG1


Cytogenetic location: 19q13.31     Genomic coordinates (GRCh38): 19:43,349,056-43,349,548 (from NCBI)


TEXT

▼ Cloning and Expression

Inactivation of the p53 tumor suppressor protein (TP53; 191170) has been observed in a large number of human cancers. Overexpression of p53 induces either growth arrest or apoptosis. The growth arrest function of p53 is mediated by induction of p21 (CDKN1A; 116899). To identify genes that may be involved in p53-dependent apoptosis, Horikoshi et al. (1999) used differential display analysis to compare mRNA from a human colon cancer cell line undergoing a very early stage of p53-induced apoptosis to mRNA from the same cell line before undergoing apoptosis. They identified 6 p53-responsive genes, PRG1 to PRG6. PRG1 was upregulated in the apoptotic cells. Northern blot analysis of the p53-induced colon cancer cell line detected a 3-kb PRG1 transcript.


▼ REFERENCES

  1. Horikoshi, N., Cong, J., Kley, N., Shenk, T. Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. Biochem. Biophys. Res. Commun. 261: 864-869, 1999. [PubMed: 10441517, related citations] [Full Text]


Creation Date:
Patti M. Sherman : 7/19/2000
Edit History:
alopez : 12/11/2014
mcapotos : 7/27/2000
psherman : 7/20/2000

* 605157

p53-RESPONSIVE GENE 1


Alternative titles; symbols

PRG1


Cytogenetic location: 19q13.31     Genomic coordinates (GRCh38): 19:43,349,056-43,349,548 (from NCBI)


TEXT

Cloning and Expression

Inactivation of the p53 tumor suppressor protein (TP53; 191170) has been observed in a large number of human cancers. Overexpression of p53 induces either growth arrest or apoptosis. The growth arrest function of p53 is mediated by induction of p21 (CDKN1A; 116899). To identify genes that may be involved in p53-dependent apoptosis, Horikoshi et al. (1999) used differential display analysis to compare mRNA from a human colon cancer cell line undergoing a very early stage of p53-induced apoptosis to mRNA from the same cell line before undergoing apoptosis. They identified 6 p53-responsive genes, PRG1 to PRG6. PRG1 was upregulated in the apoptotic cells. Northern blot analysis of the p53-induced colon cancer cell line detected a 3-kb PRG1 transcript.


REFERENCES

  1. Horikoshi, N., Cong, J., Kley, N., Shenk, T. Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. Biochem. Biophys. Res. Commun. 261: 864-869, 1999. [PubMed: 10441517] [Full Text: https://doi.org/10.1006/bbrc.1999.1123]


Creation Date:
Patti M. Sherman : 7/19/2000

Edit History:
alopez : 12/11/2014
mcapotos : 7/27/2000
psherman : 7/20/2000



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 14, 2024