Alternative titles; symbols
HGNC Approved Gene Symbol: NXPH2
Cytogenetic location: 2q22.1 Genomic coordinates (GRCh38): 2:138,669,157-138,780,390 (from NCBI)
Mammalian neurexophilin was discovered as a 29-kD neuronal glycoprotein that copurifies in a tight complex with neurexin I-alpha (600565) (Petrenko et al., 1996). By searching sequence databases using the amino acid sequence of mammalian neurexophilin as the query, Missler and Sudhof (1998) identified human ESTs corresponding to neurexophilins-1 (NXPH1; 604639), -2 (NXPH2), -3 (NXPH3; 604636), and -4 (NXPH4; 604637). Comparison of the amino acid sequences of human, rat, mouse, and bovine neurexophilins revealed that neurexophilins share a common predicted structure composed of 5 domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Northern blot analysis of a variety of human tissues detected NXPH2 expression in brain and kidney. Missler and Sudhof (1998) concluded that neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis. They suggested that neurexophilins are signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Missler, M., Sudhof, T. C. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J. Neurosci. 18: 3630-3638, 1998. [PubMed: 9570794] [Full Text: https://doi.org/10.1523/JNEUROSCI.18-10-03630.1998]
Petrenko, A. G., Ullrich, B., Missler, M., Krasnoperov, V., Rosahl, T. W., Sudhof, T. C. Structure and evolution of neurexophilin. J. Neurosci. 16: 4360-4369, 1996. [PubMed: 8699246] [Full Text: http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=8699246]