Alternative titles; symbols
HGNC Approved Gene Symbol: MEGF9
Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,600,811-120,714,470 (from NCBI)
The domain that characterizes epidermal growth factor (EGF; 131530) consists of approximately 50 amino acids with 3 disulfide bonds. EGF-like domains are believed to play a critical role in a number of extracellular events, including cell adhesion and receptor-ligand interactions. Proteins with EGF-like domains often consist of more than 1,000 amino acids, have multiple copies of the EGF-like domain, and contain additional domains known to be involved in specific protein-protein interactions. To identify proteins containing EGF-like domains, Nakayama et al. (1998) searched a database of long cDNA sequences randomly selected from a human brain cDNA library for those that encode an EGF-like motif. They identified several partial cDNAs encoding novel proteins with EGF-like domains, such as EGFL5, which they named MEGF9. The predicted partial EGFL5 protein has an EGF-like domain, 3 laminin (e.g., 150240)-type EGF-like domains, and a transmembrane domain. Northern blot analysis of various regions of rat brain detected Megf9 expression predominantly in the cerebellum.
Using a radiation hybrid mapping panel, Nakayama et al. (1998) mapped the EGFL5 gene to 9q32-q33.3.
Nakayama, M., Nakajima, D., Nagase, T., Nomura, N., Seki, N., Ohara, O. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Genomics 51: 27-34, 1998. [PubMed: 9693030] [Full Text: https://doi.org/10.1006/geno.1998.5341]