HGNC Approved Gene Symbol: RPL7
Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,290,242-73,294,466 (from NCBI)
The mammalian ribosome is composed of 4 RNA species (see 180450) and approximately 80 different proteins (see 180466).
Meyuhas and Klein (1990) identified a transcriptionally active mouse Rpl7 gene.
By screening cDNA libraries derived from activated human T-lymphocyte cell lines with a mouse Rpl7 cDNA, Hemmerich et al. (1993) isolated human RPL7 cDNAs. The predicted 248-amino acid human RPL7 protein has an N-terminal basic leucine zipper (bZIP)-like domain and the RNP consensus submotif RNP2.
Meyuhas and Klein (1990) determined that the 3.1-kb mouse Rpl7 gene contains 7 exons and encodes an mRNA that is 897 nucleotides long.
Seshadri et al. (1993) partially sequenced the human RPL7 gene and found that it shares many features with those of mouse Rpl7, including the position of the first intron and the polypyrimidine translation control element in the 5-prime noncoding region.
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the human RPL7 gene to 8q.
Sapi et al. (1994) identified a processed pseudogene for ribosomal protein L7 (RPL7P) within intron 1 of the FMS gene (164770). This pseudogene was not actively transcribed.
Hemmerich et al. (1993) demonstrated that the N-terminal region of mammalian RPL7 proteins mediates RPL7 homodimerization and stable binding of RPL7 to DNA and RNA in vitro. They found that RPL7 preferentially binds to 28S rRNA and mRNA. Hemmerich et al. (1993) showed that mouse Rpl7 mRNA is induced upon activation of resting B and T lymphocytes.
The RPL7 protein has been shown to be an autoantigen in patients with systemic lupus erythematosus (152700) and other systemic autoimmune diseases (Absi et al., 1989; von Mikecz et al., 1994; Neu et al., 1995; von Mikecz et al., 1995).
Absi, M., La Vergne, J. P., Marzouki, A., Giraud, F., Rigal, D., Reboud, A. M., Reboud, J. P., Monier, J. C. Heterogeneity of ribosomal autoantibodies from human, murine and canine connective tissue diseases. Immun. Lett. 23: 35-41, 1989. [PubMed: 2606513] [Full Text: https://doi.org/10.1016/0165-2478(89)90152-1]
Hemmerich, P., von Mikecz, A., Neumann, F., Sozeri, O., Wolff-Vorbeck, G., Zoebelein, R., Krawinkel, U. Structural and functional properties of ribosomal protein L7 from humans and rodents. Nucleic Acids Res. 21: 223-231, 1993. [PubMed: 8441630] [Full Text: https://doi.org/10.1093/nar/21.2.223]
Kenmochi, N., Kawaguchi, T., Rozen, S., Davis, E., Goodman, N., Hudson, T. J., Tanaka, T., Page, D. C. A map of 75 human ribosomal protein genes. Genome Res. 8: 509-523, 1998. [PubMed: 9582194] [Full Text: https://doi.org/10.1101/gr.8.5.509]
Meyuhas, O., Klein, A. The mouse ribosomal protein L7 gene: its primary structure and functional analysis of the promoter region. J. Biol. Chem. 265: 11465-11473, 1990. [PubMed: 2365680]
Neu, E., von Mikecz, A. H., Hemmerich, P. H., Peter, H. H., Fricke, M., Deicher, H., Genth, E., Krawinkel, U. Autoantibodies against eukaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis: frequency and correlation with clinical, serological and genetic parameters. The SLE Study Group. Clin. Exp. Immun. 100: 198-204, 1995. [PubMed: 7743655] [Full Text: https://doi.org/10.1111/j.1365-2249.1995.tb03653.x]
Sapi, E., Flick, M. B., Kacinski, B. M. The first intron of human c-fms proto-oncogene contains a processed pseudogene (RPL7P) for ribosomal protein L7. Genomics 22: 641-645, 1994. [PubMed: 8001978] [Full Text: https://doi.org/10.1006/geno.1994.1440]
Seshadri, T., Uzman, J. A., Oshima, J., Campisi, J. Identification of a transcript that is down-regulated in senescent human fibroblasts. J. Biol. Chem. 268: 18474-18480, 1993. [PubMed: 8360149]
von Mikecz, A. H., Hemmerich, P. H., Peter, H. H., Krawinkel, U. Autoantigenic epitopes on eukaryotic L7. Clin. Exp. Immun. 100: 205-213, 1995. [PubMed: 7743656] [Full Text: https://doi.org/10.1111/j.1365-2249.1995.tb03654.x]
von Mikecz, A., Hemmerich, P., Peter, H. H., Krawinkel, U. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. Immunobiology 192: 137-154, 1994. [PubMed: 7750987] [Full Text: https://doi.org/10.1016/S0171-2985(11)80413-4]