Entry - 603998 - ZINC FINGER PROTEIN 119; ZNF119 - OMIM

 
 
603998

ZINC FINGER PROTEIN 119; ZNF119


Cytogenetic location: 19p13.1-p12     Genomic coordinates (GRCh38): 19:12,600,001-24,200,000


TEXT

▼ Description

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.

▼ Cloning and Expression

By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF119. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.


▼ Mapping

Bellefroid et al. (1993) mapped YAC clones containing ZNF91-related genes by FISH and found that most of these genes, including ZNF119, are clustered in 19p13.1-p12.


▼ REFERENCES

  1. Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795, related citations] [Full Text]


Creation Date:
Patti M. Sherman : 7/9/1999
Edit History:
carol : 02/25/2020
psherman : 07/20/1999
mgross : 7/13/1999
psherman : 7/9/1999

603998

ZINC FINGER PROTEIN 119; ZNF119


Cytogenetic location: 19p13.1-p12     Genomic coordinates (GRCh38): 19:12,600,001-24,200,000


TEXT

Description

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.

Cloning and Expression

By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF119. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.


Mapping

Bellefroid et al. (1993) mapped YAC clones containing ZNF91-related genes by FISH and found that most of these genes, including ZNF119, are clustered in 19p13.1-p12.


REFERENCES

  1. Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0261-4189&date=1993&volume=12&issue=4&spage=1363]


Creation Date:
Patti M. Sherman : 7/9/1999

Edit History:
carol : 02/25/2020
psherman : 07/20/1999
mgross : 7/13/1999
psherman : 7/9/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 29, 2024