HGNC Approved Gene Symbol: ZNF112
Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:44,326,553-44,367,217 (from NCBI)
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.
By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF112. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.
Bellefroid et al. (1993) mapped YAC clones containing ZNF91-related genes by FISH and found that most of these genes, including ZNF112, are clustered in 19p13.1-p12.
Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0261-4189&date=1993&volume=12&issue=4&spage=1363]