Entry - *603880 - SOLUTE CARRIER FAMILY 16 (MONOCARBOXYLIC ACID TRANSPORTER), MEMBER 6; SLC16A6 - OMIM

 
 
* 603880

SOLUTE CARRIER FAMILY 16 (MONOCARBOXYLIC ACID TRANSPORTER), MEMBER 6; SLC16A6


Alternative titles; symbols

MONOCARBOXYLATE TRANSPORTER 7; MCT7


HGNC Approved Gene Symbol: SLC16A6

Cytogenetic location: 17q24.2     Genomic coordinates (GRCh38): 17:68,267,026-68,291,479 (from NCBI)


▼ TEXT

For general information on the monocarboxylate transporter (MCT) family, see MCT4 (SLC16A3; 603877).

▼ Cloning and Expression

Using sequence data obtained from searching an EST database with the protein sequences of several MCTs, Price et al. (1998) screened a human circulating-blood cDNA library and isolated a full-length cDNA encoding MCT7. The MCT7 cDNA predicts a 523-amino acid protein with 10 to 12 transmembrane domains. MCT7 shares between 27% and 34% amino acid identity with MCT1 (600682), MCT2 (603654), MCT4, MCT5 (603878), and MCT6 (603879). Northern blot analysis detected a 3.6-kb MCT7 mRNA in human tissues; compared to other family members, MCT7 has a unique tissue distribution.


▼ Nomenclature

Yoon et al. (1999) noted that the SLC16A6 gene was originally called MCT6 but was subsequently renamed MCT7.


▼ REFERENCES

  1. Price, N. T., Jackson, V. N., Halestrap, A. P. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329: 321-328, 1998. [PubMed: 9425115, related citations] [Full Text]

  2. Yoon, H., Donoso, L. A., Philp, N. J. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics 60: 366-370, 1999. [PubMed: 10493836, related citations] [Full Text]


Contributors:
Patricia A. Hartz - updated : 09/14/2006
Creation Date:
Stefanie A. Nelson : 6/7/1999
Edit History:
wwang : 09/14/2006
mgross : 2/6/2003
psherman : 6/7/1999

* 603880

SOLUTE CARRIER FAMILY 16 (MONOCARBOXYLIC ACID TRANSPORTER), MEMBER 6; SLC16A6


Alternative titles; symbols

MONOCARBOXYLATE TRANSPORTER 7; MCT7


HGNC Approved Gene Symbol: SLC16A6

Cytogenetic location: 17q24.2     Genomic coordinates (GRCh38): 17:68,267,026-68,291,479 (from NCBI)


TEXT

For general information on the monocarboxylate transporter (MCT) family, see MCT4 (SLC16A3; 603877).

Cloning and Expression

Using sequence data obtained from searching an EST database with the protein sequences of several MCTs, Price et al. (1998) screened a human circulating-blood cDNA library and isolated a full-length cDNA encoding MCT7. The MCT7 cDNA predicts a 523-amino acid protein with 10 to 12 transmembrane domains. MCT7 shares between 27% and 34% amino acid identity with MCT1 (600682), MCT2 (603654), MCT4, MCT5 (603878), and MCT6 (603879). Northern blot analysis detected a 3.6-kb MCT7 mRNA in human tissues; compared to other family members, MCT7 has a unique tissue distribution.


Nomenclature

Yoon et al. (1999) noted that the SLC16A6 gene was originally called MCT6 but was subsequently renamed MCT7.


REFERENCES

  1. Price, N. T., Jackson, V. N., Halestrap, A. P. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329: 321-328, 1998. [PubMed: 9425115] [Full Text: https://doi.org/10.1042/bj3290321]

  2. Yoon, H., Donoso, L. A., Philp, N. J. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics 60: 366-370, 1999. [PubMed: 10493836] [Full Text: https://doi.org/10.1006/geno.1999.5926]


Contributors:
Patricia A. Hartz - updated : 09/14/2006

Creation Date:
Stefanie A. Nelson : 6/7/1999

Edit History:
wwang : 09/14/2006
mgross : 2/6/2003
psherman : 6/7/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 18, 2024