Entry - *602831 - H4 CLUSTERED HISTONE 13; H4C13 - OMIM

 
 
* 602831

H4 CLUSTERED HISTONE 13; H4C13


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER L; HIST1H4L
HISTONE GENE CLUSTER 1, H4L
HIST1 CLUSTER, H4L
H4 HISTONE FAMILY, MEMBER K; H4FK
H4/K


HGNC Approved Gene Symbol: H4C13

Cytogenetic location: 6p22.1     Genomic coordinates (GRCh38): 6:27,873,148-27,873,534 (from NCBI)


▼ TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

▼ Cloning and Expression

Albig et al. (1997) identified a gene, designated H4/k, encoding a member of the H4 class of histones.

By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H4L gene. All H4 genes, including HIST1H4L, encode the same protein.


▼ Mapping

By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H4/k, located 2 Mb centromeric to the major histone gene cluster.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4L.


▼ Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

▼ REFERENCES

  1. Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656, related citations] [Full Text]

  2. Albig, W., Meergans, T., Doenecke, D. Characterization of the H1.5 gene completes the set of human H1 subtype genes. Gene 184: 141-148, 1997. [PubMed: 9031620, related citations] [Full Text]

  3. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 02/07/2013
Creation Date:
Rebekah S. Rasooly : 7/10/1998
Edit History:
mgross : 04/21/2022
mgross : 02/07/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998

* 602831

H4 CLUSTERED HISTONE 13; H4C13


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER L; HIST1H4L
HISTONE GENE CLUSTER 1, H4L
HIST1 CLUSTER, H4L
H4 HISTONE FAMILY, MEMBER K; H4FK
H4/K


HGNC Approved Gene Symbol: H4C13

Cytogenetic location: 6p22.1     Genomic coordinates (GRCh38): 6:27,873,148-27,873,534 (from NCBI)


TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

Cloning and Expression

Albig et al. (1997) identified a gene, designated H4/k, encoding a member of the H4 class of histones.

By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H4L gene. All H4 genes, including HIST1H4L, encode the same protein.


Mapping

By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H4/k, located 2 Mb centromeric to the major histone gene cluster.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4L.


Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

REFERENCES

  1. Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]

  2. Albig, W., Meergans, T., Doenecke, D. Characterization of the H1.5 gene completes the set of human H1 subtype genes. Gene 184: 141-148, 1997. [PubMed: 9031620] [Full Text: https://doi.org/10.1016/s0378-1119(96)00582-3]

  3. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]


Contributors:
Matthew B. Gross - updated : 02/07/2013

Creation Date:
Rebekah S. Rasooly : 7/10/1998

Edit History:
mgross : 04/21/2022
mgross : 02/07/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 14, 2024