Entry - *602829 - H4 CLUSTERED HISTONE 2; H4C2 - OMIM

 
 
* 602829

H4 CLUSTERED HISTONE 2; H4C2


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER B; HIST1H4B
HISTONE GENE CLUSTER 1, H4B
HIST1 CLUSTER, H4B
H4 HISTONE FAMILY, MEMBER I; H4FI
H4/I


HGNC Approved Gene Symbol: H4C2

Cytogenetic location: 6p22.2     Genomic coordinates (GRCh38): 6:26,026,896-26,027,283 (from NCBI)


▼ TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

▼ Cloning and Expression

By genomic sequence analysis, Marzluff et al. (2002) identified the mouse and human HIST1H4B genes. All mouse and human H4 genes, including HIST1H4B, encode the same protein.


▼ Mapping

By analysis of a YAC contig from 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes, including H4/i.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4B.


▼ Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

▼ REFERENCES

  1. Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399, related citations] [Full Text]

  2. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 02/07/2013
Creation Date:
Rebekah S. Rasooly : 7/10/1998
Edit History:
mgross : 04/21/2022
mgross : 02/07/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998

* 602829

H4 CLUSTERED HISTONE 2; H4C2


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER B; HIST1H4B
HISTONE GENE CLUSTER 1, H4B
HIST1 CLUSTER, H4B
H4 HISTONE FAMILY, MEMBER I; H4FI
H4/I


HGNC Approved Gene Symbol: H4C2

Cytogenetic location: 6p22.2     Genomic coordinates (GRCh38): 6:26,026,896-26,027,283 (from NCBI)


TEXT

For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

Cloning and Expression

By genomic sequence analysis, Marzluff et al. (2002) identified the mouse and human HIST1H4B genes. All mouse and human H4 genes, including HIST1H4B, encode the same protein.


Mapping

By analysis of a YAC contig from 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes, including H4/i.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4B.


Gene Function

See HIST1H4A (602822) for functional information on H4 histones.

REFERENCES

  1. Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]

  2. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]


Contributors:
Matthew B. Gross - updated : 02/07/2013

Creation Date:
Rebekah S. Rasooly : 7/10/1998

Edit History:
mgross : 04/21/2022
mgross : 02/07/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 14, 2024