Alternative titles; symbols
HGNC Approved Gene Symbol: PPP1R14B
Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,244,479-64,246,943 (from NCBI)
Using a cosmid that contained the gene for phospholipase C-beta-3 (PLCB3; 600230), Lagercrantz et al. (1996) isolated and characterized a gene that they called PLCB3-neighboring gene (PNG). PNG showed expression of a 1-kb message in multiple tissues. The predicted protein contains 119 amino acids.
Lagercrantz et al. (1996) described the isolation and expression of the murine PNG homolog. The predicted murine protein contains 203 amino acids.
Lagercrantz et al. (1996) determined that the PNG gene spans approximately 2.5 kb and contains 4 exons.
Lagercrantz et al. (1996) mapped the PNG gene on chromosome 11q13. It is located 4.4 kb upstream of PLCB3, with the 5-prime ends of each gene facing each other. The intragenic region showed separate CpG islands at each end separated by a stretch of 2 kb, characterized by periodic alteration of the GC content. A 5-prime flanking region of PNG did not contain TATA or CCAAT, suggesting to the authors a housekeeping promoter structure. Analysis of hybridization to a panel of somatic cell hybrids indicated the existence of related sequences on chromosomes 2, 4, 7, and 22.
Lagercrantz, J., Carson, E., Larsson, C., Nordenskjold, M., Weber, G. Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta-3 gene on chromosomal region 11q13. Genomics 31: 380-384, 1996. [PubMed: 8838322] [Full Text: https://doi.org/10.1006/geno.1996.0063]
Lagercrantz, J., Kedra, D., Carson, E., Nordenskjold, M., Dumanski, J. P., Weber, G., Piehl, F. Sequence and expression of the mouse homologue to human phospholipase C beta-3 neighboring gene. Biochem. Biophys. Res. Commun. 223: 335-340, 1996. [PubMed: 8670283] [Full Text: https://doi.org/10.1006/bbrc.1996.0895]