Alternative titles; symbols
HGNC Approved Gene Symbol: RHPN1
Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,364,255-143,384,221 (from NCBI)
The rho GTPase (see Ridley and Hall, 1992) is involved in a signaling pathway that regulates cell adhesion and cytokinesis, among other activities. Watanabe et al. (1996) used the yeast 2-hybrid system to identify cDNAs that interact with rho. One clone was isolated from a mouse embryo cDNA library. A full-length sequence derived from several clones encodes a predicted 643-amino acid protein that they named rhophilin. Northern blots showed a 3.2-kb RNA was expressed at highest amounts in the testis. Watanabe et al. (1996) found that a region at the amino terminus of rhophilin shares sequence similarity with PKN (601032) and is the site for rho binding.
Gross (2014) mapped the RHPN1 gene to chromosome 8q24.3 based on an alignment of the RHPN1 sequence (GenBank AY082588) with the genomic sequence (GRCh38).
Gross, M. B. Personal Communication. Baltimore, Md. 7/28/2014.
Ridley, A. J., Hall, A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399, 1992. [PubMed: 1643657] [Full Text: https://doi.org/10.1016/0092-8674(92)90163-7]
Watanabe, G., Saito, Y., Madaule, P., Ishizaki, T., Fujisawa, K., Morii, N., Mukai, H., Ono, Y., Kakizuka, A., Narumiya, S. Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase rho. Science 271: 645-648, 1996. [PubMed: 8571126] [Full Text: https://doi.org/10.1126/science.271.5249.645]