Mast Cell Activation Disorders
A spectrum of primary, secondary, and idiopathic disorders involving MAST CELLS and characterized by an aberrant release of mast cell mediators which result in multiple and variable inflammatory and allergic symptoms. These disorders are associated with various mutations in tyrosine kinase KIT (PROTO-ONCOGENE PROTEINS C-KIT) and other genes, underlying conditions, and responses to allergic or non-allergic triggers of mast cell stimulation and degranulation such as local anesthetics, lactam antibiotics, muscle relaxants, specific foods, environmental toxins, physical conditions such as vibration, cold, pressure, and stress.
Year introduced: 2022
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Subheadings:
Tree Number(s): C20.762
MeSH Unique ID: D000090362
Entry Terms:
- Mast Cell Activation Disease
- Mast Cell Disease
- Mast Cell Diseases
- Mast-Cell Disease
- Mast-Cell Diseases
- Primary Mast Cell Activation Disorders
- Clonal Mast Cell Proliferation Disorders
- Monoclonal Mast Cell Activation Syndrome