From HPO
Gastrointestinal hemorrhage- MedGen UID:
- 8971
- •Concept ID:
- C0017181
- •
- Pathologic Function
Hemorrhage affecting the gastrointestinal tract.
Epistaxis- MedGen UID:
- 4996
- •Concept ID:
- C0014591
- •
- Pathologic Function
Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
Myelofibrosis- MedGen UID:
- 10146
- •Concept ID:
- C0026987
- •
- Neoplastic Process
Replacement of bone marrow by fibrous tissue.
Thrombocytopenia- MedGen UID:
- 52737
- •Concept ID:
- C0040034
- •
- Disease or Syndrome
A reduction in the number of circulating thrombocytes.
Prolonged bleeding time- MedGen UID:
- 56231
- •Concept ID:
- C0151529
- •
- Finding
Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.
Increased RBC distribution width- MedGen UID:
- 1630967
- •Concept ID:
- C0948014
- •
- Finding
Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.
Abnormal bleeding- MedGen UID:
- 264316
- •Concept ID:
- C1458140
- •
- Pathologic Function
An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
Macrothrombocytopenia- MedGen UID:
- 414334
- •Concept ID:
- C2751260
- •
- Disease or Syndrome
Reduced prothrombin consumption- MedGen UID:
- 867367
- •Concept ID:
- C4021732
- •
- Finding
The prothrombin consumption test measures the formation of intrinsic thromboplastin by determining the residual serum prothrombin after blood clotting is complete. If there is a defect in the process, less prothrombin will be converted to thrombin than normal (less prothrombin is consumed). This test may be abnormal with conditions including deficiency of factors VIII or IX, with circulating anticoagulants, thrombocytopenia.
Absence of alpha granules- MedGen UID:
- 868470
- •Concept ID:
- C4022864
- •
- Finding
A lack of platelet alpha granules. This typically results in the gray appearance of platelets in giemsa stained blood smears.
Prolonged bleeding following procedure- MedGen UID:
- 868737
- •Concept ID:
- C4023142
- •
- Finding
Prolonged or protracted bleeding following an invasive procedure or intervention.
Impaired collagen-induced platelet aggregation- MedGen UID:
- 870264
- •Concept ID:
- C4024703
- •
- Finding
Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.
Impaired epinephrine-induced platelet aggregation- MedGen UID:
- 870285
- •Concept ID:
- C4024727
- •
- Finding
Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine.
Ecchymosis- MedGen UID:
- 8524
- •Concept ID:
- C0013491
- •
- Finding
A purpuric lesion that is larger than 1 cm in diameter.
Petechiae- MedGen UID:
- 10680
- •Concept ID:
- C0031256
- •
- Disease or Syndrome
Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.
Bruising susceptibility- MedGen UID:
- 140849
- •Concept ID:
- C0423798
- •
- Finding
An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
- Abnormality of blood and blood-forming tissues
- Abnormality of the digestive system
- Abnormality of the integument