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Oropharyngeal Poorly Differentiated Carcinoma

MedGen UID:
926082
•Concept ID:
C4288550
•
Neoplastic Process

Definition

A high-grade carcinoma that arises from the oropharynx. It is characterized by the presence of malignant cells which bear minimal resemblance to the cells from which they arose. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Poorly Differentiated Carcinoma

Professional guidelines

PubMed

Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy.
Taguchi T, Nishimura G, Takahashi M, Shiono O, Komatsu M, Sano D, Yabuki KI, Arai Y, Yamashita Y, Yamamoto K, Sakuma Y, Oridate N
Int J Clin Oncol 2016 Oct;21(5):869-874. Epub 2016 Feb 23 doi: 10.1007/s10147-016-0964-2. PMID: 26908193
The management of extrapulmonary poorly differentiated (high-grade) neuroendocrine carcinomas.
Smith J, Reidy-Lagunes D
Semin Oncol 2013 Feb;40(1):100-8. doi: 10.1053/j.seminoncol.2012.11.011. PMID: 23391117

Recent clinical studies

Etiology

Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Alkhatib HH, Maroun CA, Amin N, Zhu G, Guller M, Herberg ME, Wu ES, Seiwert TY, Rooper LM, Eisele DW, Fakhry C, Pardoll D, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jun 1;148(6):540-546. doi: 10.1001/jamaoto.2022.0640. PMID: 35482301Free PMC Article
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article

Diagnosis

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Incidence and Risk Factors of Distant Metastases of Head and Neck Carcinoma.
Uhliarová B, Švec M
Klin Onkol 2019 Summer;32(4):294-299. doi: 10.14735/amko2019294. PMID: 31426646
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article

Therapy

Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy.
Taguchi T, Nishimura G, Takahashi M, Shiono O, Komatsu M, Sano D, Yabuki KI, Arai Y, Yamashita Y, Yamamoto K, Sakuma Y, Oridate N
Int J Clin Oncol 2016 Oct;21(5):869-874. Epub 2016 Feb 23 doi: 10.1007/s10147-016-0964-2. PMID: 26908193
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
The role of human papillomavirus infection in head and neck cancers.
Syrjänen S
Ann Oncol 2010 Oct;21 Suppl 7:vii243-5. doi: 10.1093/annonc/mdq454. PMID: 20943622
Recent data about the role of human papillomavirus (HPV) in oncogenesis of head and neck cancer.
Bădulescu F, Crişan A, Bădulescu A, Schenker M
Rom J Morphol Embryol 2010;51(3):437-40. PMID: 20809017
Poorly differentiated naso- and oropharyngeal carcinoma. A retrospective comparison between the results of radiotherapy alone and radiotherapy plus adjuvant methotrexate.
Reinfuss M, Skołyszewski J, Radkowski A
Acta Oncol 1991;30(1):39-43. doi: 10.3109/02841869109091811. PMID: 2009183

Prognosis

Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Alkhatib HH, Maroun CA, Amin N, Zhu G, Guller M, Herberg ME, Wu ES, Seiwert TY, Rooper LM, Eisele DW, Fakhry C, Pardoll D, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jun 1;148(6):540-546. doi: 10.1001/jamaoto.2022.0640. PMID: 35482301Free PMC Article
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Prevalence and prognosis of synchronous distant metastatic tonsil squamous cell carcinomas.
Li Y, Hu C
Int J Med Sci 2021;18(2):528-533. Epub 2021 Jan 1 doi: 10.7150/ijms.50966. PMID: 33390822Free PMC Article
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604

Clinical prediction guides

Tumor Histological Grade and Immunotherapy Response in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Alkhatib HH, Maroun CA, Amin N, Zhu G, Guller M, Herberg ME, Wu ES, Seiwert TY, Rooper LM, Eisele DW, Fakhry C, Pardoll D, Mandal R
JAMA Otolaryngol Head Neck Surg 2022 Jun 1;148(6):540-546. doi: 10.1001/jamaoto.2022.0640. PMID: 35482301Free PMC Article
A proposal for classification of oropharyngeal squamous cell carcinoma: Morphology and status of HPV by immunohistochemistry and molecular biology.
Rahimi S, Akaev I, Brennan PA, Virgo A, Marani C, Gomez RS, Yeoh CC
J Oral Pathol Med 2020 Feb;49(2):110-116. Epub 2019 Sep 10 doi: 10.1111/jop.12956. PMID: 31465605
Poorly differentiated neuroendocrine carcinoma of the head and neck: human papillomavirus tumour status/p16 status and impact on overall survival.
Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M
Histopathology 2020 Mar;76(4):581-591. Epub 2020 Jan 24 doi: 10.1111/his.13982. PMID: 31463946
Clinicopathological features, management and outcome of patients with poorly-differentiated oral and oropharyngeal squamous cell carcinoma.
Feng Z, Xu QS, Wang C, Li B, Li JZ, Mao MH, Li H, Qin LZ, Han Z
J Craniomaxillofac Surg 2017 Sep;45(9):1478-1485. Epub 2017 Jul 4 doi: 10.1016/j.jcms.2017.06.013. PMID: 28743604
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223

Recent systematic reviews

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article

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