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Osseous metaplasia

MedGen UID:
90738
•Concept ID:
C0334040
•
Pathologic Function
Synonyms: Bone Metaplasia; Extraskeletal ossification; Metaplastic ossification; Osseous Metaplasia; Osteosis
SNOMED CT: Osseous metaplasia (38109001); Metaplastic ossification (38109001); Extraskeletal ossification (38109001); Osteosis (38109001)

Definition

Heterotopic formation of normal bone within soft tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsseous metaplasia

Professional guidelines

PubMed

Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis.
Yao H, Wang B, Wen L, Jin Q, Li H, Huang G, Yin J, Zou C, Xie X, Shen J
BMC Cancer 2018 Nov 29;18(1):1195. doi: 10.1186/s12885-018-5062-6. PMID: 30497436Free PMC Article
Anti-angiogenic therapy, a new player in the field of sarcoma treatment.
Versleijen-Jonkers YM, Vlenterie M, van de Luijtgaarden AC, van der Graaf WT
Crit Rev Oncol Hematol 2014 Aug;91(2):172-85. Epub 2014 Feb 15 doi: 10.1016/j.critrevonc.2014.02.001. PMID: 24613529
Interventional management of hypervascular osseous metastasis: role of embolotherapy before orthopedic tumor resection and bone stabilization.
Kickuth R, Waldherr C, Hoppe H, Bonel HM, Ludwig K, Beck M, Triller J
AJR Am J Roentgenol 2008 Dec;191(6):W240-7. doi: 10.2214/AJR.07.4037. PMID: 19020210

Recent clinical studies

Etiology

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Osseous metaplasia of the endometrium: A multicenter retrospective study.
Garzon S, Laganà AS, Carugno J, Cayuela Font E, Jimenez J, Kar S, Fikri J, Carlos Pons J, Milind T, Medvedied M, Alonso Pacheco L, Salazar E, Montevecchi L, Ochoa CM, De Angelis C
Eur J Obstet Gynecol Reprod Biol 2021 Oct;265:150-155. Epub 2021 Sep 1 doi: 10.1016/j.ejogrb.2021.08.032. PMID: 34500212
Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review.
Razafimahefa J, Gosset C, Mongiat-Artus P, Andriamampionona TF, Verine J
Diagn Pathol 2019 Jul 13;14(1):75. doi: 10.1186/s13000-019-0851-z. PMID: 31299983Free PMC Article
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747
Osseous metaplasia of the endometrium and successful hysteroscopic resection: a report of two cases and a review of the literature.
Madaan M, Suman S, Sharma R, Kapoor N, Garg P, Raj SS
Asian J Endosc Surg 2015 Feb;8(1):63-6. doi: 10.1111/ases.12153. PMID: 25598057

Diagnosis

Osseous metaplasia of the endometrium: A multicenter retrospective study.
Garzon S, Laganà AS, Carugno J, Cayuela Font E, Jimenez J, Kar S, Fikri J, Carlos Pons J, Milind T, Medvedied M, Alonso Pacheco L, Salazar E, Montevecchi L, Ochoa CM, De Angelis C
Eur J Obstet Gynecol Reprod Biol 2021 Oct;265:150-155. Epub 2021 Sep 1 doi: 10.1016/j.ejogrb.2021.08.032. PMID: 34500212
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Thoracic psammomatous meningioma with osseous metaplasia: a controversial diagnosis of a case report and literature review.
Wang C, Chen Y, Zhang L, Ma X, Chen B, Li S
World J Surg Oncol 2019 Aug 24;17(1):150. doi: 10.1186/s12957-019-1694-5. PMID: 31445511Free PMC Article
Intraocular ossification. Case report.
Maftei C, Stanca HT
Rom J Ophthalmol 2017 Jan-Mar;61(1):65-68. doi: 10.22336/rjo.2017.12. PMID: 29450374Free PMC Article
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747

Therapy

Endometrial Osseous Metaplasia-A Rare Cause of Infertility with Unknown Etiology.
Tica VI, Postolache I, Boșoteanu M, Aschie M, Tica I, Orasanu CI, Penciu RC, Tica AA, Steriu L, De Wilde RL, Tica OS
Medicina (Kaunas) 2023 Oct 10;59(10) doi: 10.3390/medicina59101803. PMID: 37893521Free PMC Article
Nephrogenic Systemic Fibrosis with Osseous Metaplasia in a Kidney-Pancreas Transplant Patient.
de Lavillandre JLB, Buron F, Ducroux E, Kanitakis J
Skinmed 2022;20(2):145-148. Epub 2022 Apr 30 PMID: 35532771
Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles.
Sanders BP, Orlando G, Peloso A, Katari RS, Iskandar SS, Farney AC, Rogers J, Soker S, Stratta RJ
Exp Clin Transplant 2014 Aug;12(4):371-3. PMID: 25095714
Osseous metaplasia of the cervix and endometrium: a case of secondary infertility.
Polat I, Sahin O, Yildirim G, Karaman E, Erim A, Tekirdag AI
Fertil Steril 2011 Jun;95(7):2434.e1-4. Epub 2011 Mar 5 doi: 10.1016/j.fertnstert.2011.02.001. PMID: 21377672
True osseous metaplasia of the endometrium: the bone is not from a fetus.
Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P
Fertil Steril 2009 Apr;91(4):1293.e1-4. Epub 2009 Jan 30 doi: 10.1016/j.fertnstert.2008.12.026. PMID: 19185859

Prognosis

The Evolving Spectrum of Endometrial Glandular Proliferations With Corded and Hyalinized Features.
Pors J, Weiel JJ, Ryan E, Longacre TA
Am J Surg Pathol 2023 Sep 1;47(9):1067-1076. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002078. PMID: 37493099
Juvenile Polyps with Osseous Metaplasia: Report of Two Pediatric Cases and Review of the Literature.
Azari-Yam A, Alimadadi H, Safavi M
Fetal Pediatr Pathol 2022 Feb;41(1):166-170. Epub 2020 May 14 doi: 10.1080/15513815.2020.1761916. PMID: 32406794
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review.
Razafimahefa J, Gosset C, Mongiat-Artus P, Andriamampionona TF, Verine J
Diagn Pathol 2019 Jul 13;14(1):75. doi: 10.1186/s13000-019-0851-z. PMID: 31299983Free PMC Article
Osseous metaplasia of the endometrium and successful hysteroscopic resection: a report of two cases and a review of the literature.
Madaan M, Suman S, Sharma R, Kapoor N, Garg P, Raj SS
Asian J Endosc Surg 2015 Feb;8(1):63-6. doi: 10.1111/ases.12153. PMID: 25598057

Clinical prediction guides

Osseous metaplasia within native cardiac valves: clinicopathologic characterization of a histologic constituent with particular focus upon aortic valves.
Pichler Sekulic S, Sekulic M
Virchows Arch 2022 Feb;480(2):425-432. Epub 2021 Sep 4 doi: 10.1007/s00428-021-03200-8. PMID: 34480613
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Clinicopathologic analysis of renal cell carcinoma containing Intratumoral fat with and without osseous metaplasia.
Xian Z, Orien JO, Box GN, Zynger DL
Diagn Pathol 2020 Mar 6;15(1):21. doi: 10.1186/s13000-020-00941-z. PMID: 32143646Free PMC Article
So-called massive retinal gliosis: A critical review and reappraisal.
Jakobiec FA, Thanos A, Stagner AM, Grossniklaus HE, Proia AD
Surv Ophthalmol 2016 May-Jun;61(3):339-56. Epub 2015 Dec 15 doi: 10.1016/j.survophthal.2015.12.002. PMID: 26703887
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747

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