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Decreased level of thrombomodulin

MedGen UID:
904486
•Concept ID:
C4255334
•
Finding
Synonym: BDCA-3
 
HPO: HP:0040229

Definition

Thrombomodulin is a cofactor in the thrombin induced activation of Protein C. In the case of deficiency there will be less Protein C and tendency to clot [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased level of thrombomodulin

Professional guidelines

PubMed

hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Cimeno A, Kuravi K, Sorrells L, Dandro A, Sendil S, Burdorf L, Parsell DM, Eyestone W, Phelps C, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC
Xenotransplantation 2022 Mar;29(2):e12731. Epub 2022 Feb 15 doi: 10.1111/xen.12731. PMID: 35166407Free PMC Article
An evaluation of the Japanese Society on Thrombosis and Hemostasis criteria for disseminated intravascular coagulation as a predictor of prognosis in patients with infection.
Madoiwa S, Honda G, Kawano N, Uchiyama T, Kawasugi K, Takezako N, Suzuki K, Seki Y, Ikezoe T, Okamoto K, Wada H
Int J Lab Hematol 2021 Dec;43(6):1566-1574. Epub 2021 Jul 6 doi: 10.1111/ijlh.13643. PMID: 34228395
Current drug treatment strategies for disseminated intravascular coagulation.
de Jonge E, Levi M, Stoutenbeek CP, van Deventer SJ
Drugs 1998 Jun;55(6):767-77. doi: 10.2165/00003495-199855060-00004. PMID: 9617592

Recent clinical studies

Etiology

The utility of inflammatory and endothelial factors in the prognosis of severe dengue.
Sivasubramanian S, Mohandas S, Gopalan V, Vimal Raj V, Govindan K, Varadarajan P, Kaveri K, Ramkumar KM
Immunobiology 2022 Nov;227(6):152289. Epub 2022 Oct 11 doi: 10.1016/j.imbio.2022.152289. PMID: 36257203
Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.
Zhu Z, Guo D, Jia Y, Zhang K, Shi M, Peng Y, Yang P, Chen J, Zhang J, Wang A, Xu T, Zhang Y, He J
Neurology 2022 Aug 30;99(9):e916-e924. Epub 2022 Jun 2 doi: 10.1212/WNL.0000000000200783. PMID: 35654592
Soluble thrombomodulin and cardiovascular disease risk factors in Japanese children.
Kikuchi T, Lin L, Horigome H
Blood Coagul Fibrinolysis 2021 Jun 1;32(4):273-277. doi: 10.1097/MBC.0000000000001035. PMID: 33955862
Thrombin Generation and Cirrhosis: State of the Art and Perspectives.
Lebreton A, Sinegre T, Lecompte T, Talon L, Abergel A, Lisman T
Semin Thromb Hemost 2020 Sep;46(6):693-703. Epub 2020 Aug 20 doi: 10.1055/s-0040-1715102. PMID: 32820480
Does uremia cause vascular dysfunction?
Brunet P, Gondouin B, Duval-Sabatier A, Dou L, Cerini C, Dignat-George F, Jourde-Chiche N, Argiles A, Burtey S
Kidney Blood Press Res 2011;34(4):284-90. Epub 2011 Jun 21 doi: 10.1159/000327131. PMID: 21691132

Diagnosis

The utility of inflammatory and endothelial factors in the prognosis of severe dengue.
Sivasubramanian S, Mohandas S, Gopalan V, Vimal Raj V, Govindan K, Varadarajan P, Kaveri K, Ramkumar KM
Immunobiology 2022 Nov;227(6):152289. Epub 2022 Oct 11 doi: 10.1016/j.imbio.2022.152289. PMID: 36257203
Therapeutic Strategies for Disseminated Intravascular Coagulation Associated with Aortic Aneurysm.
Yamada S, Asakura H
Int J Mol Sci 2022 Jan 24;23(3) doi: 10.3390/ijms23031296. PMID: 35163216Free PMC Article
Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort.
Blondon M, Bodmer A, Thouvenin L, Lecompte T, Righini M, Fontana P, Casini A
Blood Adv 2022 May 10;6(9):2884-2892. doi: 10.1182/bloodadvances.2021006623. PMID: 35086148Free PMC Article
Thrombin Generation and Cirrhosis: State of the Art and Perspectives.
Lebreton A, Sinegre T, Lecompte T, Talon L, Abergel A, Lisman T
Semin Thromb Hemost 2020 Sep;46(6):693-703. Epub 2020 Aug 20 doi: 10.1055/s-0040-1715102. PMID: 32820480
Hemostasis biomarkers in multiple sclerosis.
Ziliotto N, Bernardi F, Jakimovski D, Baroni M, Marchetti G, Bergsland N, Ramasamy DP, Weinstock-Guttman B, Schweser F, Zamboni P, Ramanathan M, Zivadinov R
Eur J Neurol 2018 Sep;25(9):1169-1176. Epub 2018 Jun 26 doi: 10.1111/ene.13681. PMID: 29758118

Therapy

Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.
Zhu Z, Guo D, Jia Y, Zhang K, Shi M, Peng Y, Yang P, Chen J, Zhang J, Wang A, Xu T, Zhang Y, He J
Neurology 2022 Aug 30;99(9):e916-e924. Epub 2022 Jun 2 doi: 10.1212/WNL.0000000000200783. PMID: 35654592
Differential impact of tamoxifen and aromatase inhibitors on thrombin generation: the prospective HEMOBREAST cohort.
Blondon M, Bodmer A, Thouvenin L, Lecompte T, Righini M, Fontana P, Casini A
Blood Adv 2022 May 10;6(9):2884-2892. doi: 10.1182/bloodadvances.2021006623. PMID: 35086148Free PMC Article
Thrombin Generation and Cirrhosis: State of the Art and Perspectives.
Lebreton A, Sinegre T, Lecompte T, Talon L, Abergel A, Lisman T
Semin Thromb Hemost 2020 Sep;46(6):693-703. Epub 2020 Aug 20 doi: 10.1055/s-0040-1715102. PMID: 32820480
Hypercoagulability in cirrhosis: causes and consequences.
Tripodi A, Anstee QM, Sogaard KK, Primignani M, Valla DC
J Thromb Haemost 2011 Sep;9(9):1713-23. doi: 10.1111/j.1538-7836.2011.04429.x. PMID: 21729237
Statins and blood coagulation.
Undas A, Brummel-Ziedins KE, Mann KG
Arterioscler Thromb Vasc Biol 2005 Feb;25(2):287-94. Epub 2004 Nov 29 doi: 10.1161/01.ATV.0000151647.14923.ec. PMID: 15569822

Prognosis

Irregularities of Coagulation in Hypertension.
Rafaqat S, Khalid A, Riaz S, Rafaqat S
Curr Hypertens Rep 2023 Oct;25(10):271-286. Epub 2023 Aug 10 doi: 10.1007/s11906-023-01258-0. PMID: 37561240
Changes in platelet levels and prognosis in patients with acute liver failure and late-onset hepatic failure.
Hayashi M, Fujita M, Abe K, Takahashi A, Ohira H
Medicine (Baltimore) 2022 Dec 2;101(48):e31438. doi: 10.1097/MD.0000000000031438. PMID: 36482586Free PMC Article
The utility of inflammatory and endothelial factors in the prognosis of severe dengue.
Sivasubramanian S, Mohandas S, Gopalan V, Vimal Raj V, Govindan K, Varadarajan P, Kaveri K, Ramkumar KM
Immunobiology 2022 Nov;227(6):152289. Epub 2022 Oct 11 doi: 10.1016/j.imbio.2022.152289. PMID: 36257203
Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.
Zhu Z, Guo D, Jia Y, Zhang K, Shi M, Peng Y, Yang P, Chen J, Zhang J, Wang A, Xu T, Zhang Y, He J
Neurology 2022 Aug 30;99(9):e916-e924. Epub 2022 Jun 2 doi: 10.1212/WNL.0000000000200783. PMID: 35654592
"Normal" thrombin generation.
Butenas S, van't Veer C, Mann KG
Blood 1999 Oct 1;94(7):2169-78. PMID: 10498586

Clinical prediction guides

Irregularities of Coagulation in Hypertension.
Rafaqat S, Khalid A, Riaz S, Rafaqat S
Curr Hypertens Rep 2023 Oct;25(10):271-286. Epub 2023 Aug 10 doi: 10.1007/s11906-023-01258-0. PMID: 37561240
The utility of inflammatory and endothelial factors in the prognosis of severe dengue.
Sivasubramanian S, Mohandas S, Gopalan V, Vimal Raj V, Govindan K, Varadarajan P, Kaveri K, Ramkumar KM
Immunobiology 2022 Nov;227(6):152289. Epub 2022 Oct 11 doi: 10.1016/j.imbio.2022.152289. PMID: 36257203
Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study.
Zhu Z, Guo D, Jia Y, Zhang K, Shi M, Peng Y, Yang P, Chen J, Zhang J, Wang A, Xu T, Zhang Y, He J
Neurology 2022 Aug 30;99(9):e916-e924. Epub 2022 Jun 2 doi: 10.1212/WNL.0000000000200783. PMID: 35654592
Statins and blood coagulation.
Undas A, Brummel-Ziedins KE, Mann KG
Arterioscler Thromb Vasc Biol 2005 Feb;25(2):287-94. Epub 2004 Nov 29 doi: 10.1161/01.ATV.0000151647.14923.ec. PMID: 15569822
Protein C.
Esmon CT
Prog Hemost Thromb 1984;7:25-54. PMID: 6099583

Recent systematic reviews

Analysis of Clinical Efficacy of Traditional Chinese Medicine in Recovery Stage of Stroke: A Systematic Review and Meta-Analysis.
Zhang X, Zhang XF, Wang L, Guo DY, Zhang JM, Chen YG, Wang ZC, Pei LS, Chen JX, Shi YJ, Zou JB
Cardiovasc Ther 2020;2020:7172052. Epub 2020 Sep 19 doi: 10.1155/2020/7172052. PMID: 33042224Free PMC Article

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