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Increased adiponectin level

MedGen UID:
892601
•Concept ID:
C4073128
•
Finding
HPO: HP:0030686

Definition

An elevated circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased adiponectin level

Professional guidelines

PubMed

The significance of anthocyanins in the prevention and treatment of type 2 diabetes.
Różańska D, Regulska-Ilow B
Adv Clin Exp Med 2018 Jan;27(1):135-142. doi: 10.17219/acem/64983. PMID: 29521054
Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management.
van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL
Obes Rev 2011 Oct;12(10):829-40. Epub 2011 Jul 12 doi: 10.1111/j.1467-789X.2011.00900.x. PMID: 21749607
Lipodystrophy: pathophysiology and advances in treatment.
Fiorenza CG, Chou SH, Mantzoros CS
Nat Rev Endocrinol 2011 Mar;7(3):137-50. Epub 2010 Nov 16 doi: 10.1038/nrendo.2010.199. PMID: 21079616Free PMC Article

Recent clinical studies

Etiology

Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
Chung SM, Moon JS, Hong JH, Hwang IC, Lim S
Diabetes Obes Metab 2023 Aug;25(8):2181-2190. Epub 2023 May 3 doi: 10.1111/dom.15095. PMID: 37046365
Effects of aerobic exercise on adiponectin levels potentially mediated by vitamin D in type 2 diabetic patients.
Mudjanarko SW, Irawati A, Tinduh D
Endocr Regul 2022 Jul 13;56(3):201-208. doi: 10.2478/enr-2022-0021. PMID: 35843714
Differential effects of leptin on adiponectin expression with weight gain versus obesity.
Singh P, Sharma P, Sahakyan KR, Davison DE, Sert-Kuniyoshi FH, Romero-Corral A, Swain JM, Jensen MD, Lopez-Jimenez F, Kara T, Somers VK
Int J Obes (Lond) 2016 Feb;40(2):266-74. Epub 2015 Sep 16 doi: 10.1038/ijo.2015.181. PMID: 26374448Free PMC Article
Increased adiponectin level in parallel with increased NT-pro BNP in patients with severe heart failure in the elderly: A hospital cohort study.
Haugen E, Furukawa Y, Isic A, Fu M
Int J Cardiol 2008 Apr 10;125(2):216-9. Epub 2008 Jan 29 doi: 10.1016/j.ijcard.2007.12.002. PMID: 18234365
Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome.
Pamuk GE, Turgut B, Demir M, Vural O
J Exp Clin Cancer Res 2006 Dec;25(4):537-41. PMID: 17310845

Diagnosis

Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
Chung SM, Moon JS, Hong JH, Hwang IC, Lim S
Diabetes Obes Metab 2023 Aug;25(8):2181-2190. Epub 2023 May 3 doi: 10.1111/dom.15095. PMID: 37046365
Metabolic Syndrome, Disease Activity, and Adipokines in Patients With Newly Diagnosed Inflammatory Joint Diseases.
Kononoff A, Vuolteenaho K, Hämäläinen M, Kautiainen H, Elfving P, Savolainen E, Arstila L, Niinisalo H, Rutanen J, Marjoniemi O, Moilanen E, Kaipiainen-Seppänen O
J Clin Rheumatol 2021 Dec 1;27(8):e349-e356. doi: 10.1097/RHU.0000000000001412. PMID: 32453216
Differential effects of leptin on adiponectin expression with weight gain versus obesity.
Singh P, Sharma P, Sahakyan KR, Davison DE, Sert-Kuniyoshi FH, Romero-Corral A, Swain JM, Jensen MD, Lopez-Jimenez F, Kara T, Somers VK
Int J Obes (Lond) 2016 Feb;40(2):266-74. Epub 2015 Sep 16 doi: 10.1038/ijo.2015.181. PMID: 26374448Free PMC Article
Increased adiponectin level in parallel with increased NT-pro BNP in patients with severe heart failure in the elderly: A hospital cohort study.
Haugen E, Furukawa Y, Isic A, Fu M
Int J Cardiol 2008 Apr 10;125(2):216-9. Epub 2008 Jan 29 doi: 10.1016/j.ijcard.2007.12.002. PMID: 18234365
Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome.
Pamuk GE, Turgut B, Demir M, Vural O
J Exp Clin Cancer Res 2006 Dec;25(4):537-41. PMID: 17310845

Therapy

Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
Chung SM, Moon JS, Hong JH, Hwang IC, Lim S
Diabetes Obes Metab 2023 Aug;25(8):2181-2190. Epub 2023 May 3 doi: 10.1111/dom.15095. PMID: 37046365
Effects of aerobic exercise on adiponectin levels potentially mediated by vitamin D in type 2 diabetic patients.
Mudjanarko SW, Irawati A, Tinduh D
Endocr Regul 2022 Jul 13;56(3):201-208. doi: 10.2478/enr-2022-0021. PMID: 35843714
Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans.
Ngatu NR, Ikeda M, Watanabe H, Tanaka M, Inoue M, Kanbara S, Nojima S
Mar Drugs 2017 Feb 8;15(2) doi: 10.3390/md15020032. PMID: 28208744Free PMC Article
Differential effects of leptin on adiponectin expression with weight gain versus obesity.
Singh P, Sharma P, Sahakyan KR, Davison DE, Sert-Kuniyoshi FH, Romero-Corral A, Swain JM, Jensen MD, Lopez-Jimenez F, Kara T, Somers VK
Int J Obes (Lond) 2016 Feb;40(2):266-74. Epub 2015 Sep 16 doi: 10.1038/ijo.2015.181. PMID: 26374448Free PMC Article
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents.
Lira FS, Rosa JC, Pimentel GD, Santos RV, Carnier J, Sanches PL, de Piano A, de Souza CT, Tock L, Tufik S, de Mello MT, Seelaender M, Oller do Nascimento CM, Oyama LM, Dâmaso AR
Nutr J 2012 Sep 18;11:74. doi: 10.1186/1475-2891-11-74. PMID: 22989045Free PMC Article

Prognosis

Increased adiponectin level in parallel with increased NT-pro BNP in patients with severe heart failure in the elderly: A hospital cohort study.
Haugen E, Furukawa Y, Isic A, Fu M
Int J Cardiol 2008 Apr 10;125(2):216-9. Epub 2008 Jan 29 doi: 10.1016/j.ijcard.2007.12.002. PMID: 18234365
Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome.
Pamuk GE, Turgut B, Demir M, Vural O
J Exp Clin Cancer Res 2006 Dec;25(4):537-41. PMID: 17310845

Clinical prediction guides

Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi-heart study.
Chung SM, Moon JS, Hong JH, Hwang IC, Lim S
Diabetes Obes Metab 2023 Aug;25(8):2181-2190. Epub 2023 May 3 doi: 10.1111/dom.15095. PMID: 37046365
miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin.
Rajan S, Panzade G, Srivastava A, Shankar K, Pandey R, Kumar D, Gupta S, Gupta A, Varshney S, Beg M, Mishra RK, Shankar R, Gaikwad A
J Endocrinol 2018 Oct 1;239(1):1–17. doi: 10.1530/JOE-17-0387. PMID: 30307150
Uncovering Adiponectin Replenishing Property of Sujiaonori Algal Biomaterial in Humans.
Ngatu NR, Ikeda M, Watanabe H, Tanaka M, Inoue M, Kanbara S, Nojima S
Mar Drugs 2017 Feb 8;15(2) doi: 10.3390/md15020032. PMID: 28208744Free PMC Article
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents.
Lira FS, Rosa JC, Pimentel GD, Santos RV, Carnier J, Sanches PL, de Piano A, de Souza CT, Tock L, Tufik S, de Mello MT, Seelaender M, Oller do Nascimento CM, Oyama LM, Dâmaso AR
Nutr J 2012 Sep 18;11:74. doi: 10.1186/1475-2891-11-74. PMID: 22989045Free PMC Article
Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome.
Pamuk GE, Turgut B, Demir M, Vural O
J Exp Clin Cancer Res 2006 Dec;25(4):537-41. PMID: 17310845

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