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Non-keratinizing sinonasal squamous cell carcinoma

MedGen UID:
83119
•Concept ID:
C0334270
•
Neoplastic Process
Synonyms: Cylindrical cell carcinoma; cylindrical cell carcinoma; Non-Keratinizing Sinonasal Squamous Cell Carcinoma; non-keratinizing sinonasal squamous cell carcinoma; Ringertz Carcinoma; Ringertz carcinoma; Schneiderian Carcinoma; Schneiderian carcinoma; Sinonasal Cylindrical Cell Carcinoma; Sinonasal cylindrical cell carcinoma; Sinonasal Non-Keratinizing Squamous Cell Carcinoma; Sinonasal Schneiderian Carcinoma; Sinonasal Schneiderian carcinoma; sinonasal squamous cell carcinoma; Sinonasal Transitional Cell Carcinoma; Sinonasal transitional cell carcinoma
SNOMED CT: Schneiderian carcinoma (5600009); Cylindrical cell carcinoma (5600009)
 
Monarch Initiative: MONDO:0002831

Definition

A squamous cell carcinoma of the sinonasal tract characterized by a plexiform or ribbon-like growth pattern, cytological atypia, and lack of histological evidence of keratinization. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-keratinizing sinonasal squamous cell carcinoma

Professional guidelines

PubMed

Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article

Recent clinical studies

Etiology

A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers.
Laforga JB, Othman BK
Rev Esp Patol 2024 Jan-Mar;57(1):67-70. Epub 2023 Oct 28 doi: 10.1016/j.patol.2023.08.002. PMID: 38246714
High-risk HPV Does not Appear to be an Important Risk Factor for Sinonasal Carcinomas in Turkish Population: A Tertiary Center Experience.
Apaydin Arikan E, Aydemir L, Ulusan M, Yilmazbayhan D, Ozluk Y
Int J Surg Pathol 2023 Apr;31(2):124-136. Epub 2022 Apr 11 doi: 10.1177/10668969221091590. PMID: 35404169
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas.
Larque AB, Hakim S, Ordi J, Nadal A, Diaz A, del Pino M, Marimon L, Alobid I, Cardesa A, Alos L
Mod Pathol 2014 Mar;27(3):343-51. Epub 2013 Sep 13 doi: 10.1038/modpathol.2013.155. PMID: 24030745
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

Diagnosis

A diagnostic algorithm for sinonasal papillary non-keratinizing squamous cell carcinoma with DEK::AFF2 fusion and mimickers.
Laforga JB, Othman BK
Rev Esp Patol 2024 Jan-Mar;57(1):67-70. Epub 2023 Oct 28 doi: 10.1016/j.patol.2023.08.002. PMID: 38246714
A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene.
Bubola J, MacMillan CM, Weinreb I, Witterick I, Swanson D, Zhang L, Antonescu CR, Dickson BC
Head Neck Pathol 2021 Dec;15(4):1284-1288. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01249-6. PMID: 33394379Free PMC Article
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Sinonasal non-keratinizing squamous cell carcinoma with nasal skin extension as the initial presentation.
Guo R, Metcalf S, Crowson AN
J Cutan Pathol 2012 Aug;39(8):791-4. Epub 2012 Jul 9 doi: 10.1111/j.1600-0560.2012.01939.x. PMID: 22775560

Prognosis

Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas.
Alos L, Hakim S, Larque AB, de la Oliva J, Rodriguez-Carunchio L, Caballero M, Nadal A, Marti C, Guimera N, Fernandez-Figueras MT, Quint W, Ordi J
Virchows Arch 2016 Sep;469(3):277-84. Epub 2016 Jul 8 doi: 10.1007/s00428-016-1982-1. PMID: 27392929
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346

Clinical prediction guides

Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article
High-risk human papillomavirus is transcriptionally active in a subset of sinonasal squamous cell carcinomas.
Larque AB, Hakim S, Ordi J, Nadal A, Diaz A, del Pino M, Marimon L, Alobid I, Cardesa A, Alos L
Mod Pathol 2014 Mar;27(3):343-51. Epub 2013 Sep 13 doi: 10.1038/modpathol.2013.155. PMID: 24030745
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article

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