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Glottis squamous cell carcinoma

MedGen UID:
76096
•Concept ID:
C0280325
•
Neoplastic Process
Synonyms: Epidermoid Carcinoma of Glottis; epidermoid carcinoma of glottis; Epidermoid Carcinoma of the Glottis; epidermoid carcinoma of the glottis; Glottic Epidermoid Carcinoma; glottic epidermoid carcinoma; Glottic Squamous Cell Carcinoma; glottic squamous cell carcinoma; Glottis Epidermoid Carcinoma; glottis epidermoid carcinoma; Glottis Squamous Cell Carcinoma; glottis squamous cell carcinoma; Squamous Cell Carcinoma of Glottis; squamous cell carcinoma of glottis; Squamous Cell Carcinoma of the Glottis; squamous cell carcinoma of the glottis
 
Monarch Initiative: MONDO:0004080

Definition

A squamous cell carcinoma of the larynx that arises from the glottic area. It may remain localized for a long period then in late disease stage, it may spread to the opposite true vocal cord, supraglottic and subglottic areas, and the soft tissues of the neck. Hoarseness is the presenting symptom. [from NCI]

Professional guidelines

PubMed

Surgical Treatment of Early Glottic Cancer.
Silver JA, Turkdogan S, Roy CF, Kost KM
Otolaryngol Clin North Am 2023 Apr;56(2):259-273. doi: 10.1016/j.otc.2022.12.009. PMID: 37030939
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Evidence-based practice: management of glottic cancer.
Hartl DM
Otolaryngol Clin North Am 2012 Oct;45(5):1143-61. Epub 2012 Jul 31 doi: 10.1016/j.otc.2012.06.014. PMID: 22980690

Recent clinical studies

Etiology

Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment.
Sigston EA, Longano A, Strzelecki AT, Williams BR
Head Neck 2016 Sep;38(9):1401-6. Epub 2016 Apr 4 doi: 10.1002/hed.24450. PMID: 27043324
Early glottic carcinoma treated by radiotherapy: defining a population for surgical salvage.
Smee RI, Williams JR, Broadley K, Bridger GP
Laryngoscope 2013 Jan;123(1):171-6. Epub 2012 Sep 24 doi: 10.1002/lary.23663. PMID: 23007323

Diagnosis

Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment.
Sigston EA, Longano A, Strzelecki AT, Williams BR
Head Neck 2016 Sep;38(9):1401-6. Epub 2016 Apr 4 doi: 10.1002/hed.24450. PMID: 27043324

Prognosis

Early glottic carcinoma treated by radiotherapy: defining a population for surgical salvage.
Smee RI, Williams JR, Broadley K, Bridger GP
Laryngoscope 2013 Jan;123(1):171-6. Epub 2012 Sep 24 doi: 10.1002/lary.23663. PMID: 23007323

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