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Childhood-Onset Systemic Lupus Erythematosus

MedGen UID:
482373
Concept ID:
C3280743
Finding
Synonym: Systemic lupus erythematosus, childhood onset

Definition

Systemic lupus erythematosus (SLE) diagnosed in individuals under the age of eighteen. Children frequently have multi-organ involvement and acute disease onset. Symptoms include fever, arthritis, skin lesions, anemia, and fatigue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood-Onset Systemic Lupus Erythematosus

Professional guidelines

PubMed

Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA
Paediatr Drugs 2021 Jul;23(4):331-347. Epub 2021 Jul 10 doi: 10.1007/s40272-021-00457-z. PMID: 34244988Free PMC Article
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Groot N, de Graeff N, Avcin T, Bader-Meunier B, Brogan P, Dolezalova P, Feldman B, Kone-Paut I, Lahdenne P, Marks SD, McCann L, Ozen S, Pilkington C, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Ann Rheum Dis 2017 Nov;76(11):1788-1796. Epub 2017 Jun 19 doi: 10.1136/annrheumdis-2016-210960. PMID: 28630236

Recent clinical studies

Etiology

Xu L, Zhao J, Sun Q, Xu X, Wang L, Liu T, Wu Y, Zhu J, Geng L, Deng Y, Awgulewitsch A, Kamen DL, Oates JC, Raj P, Wakeland EK, Scofield RH, Guthridge JM, James JA, Hahn BH, McCurdy DK, Wang F, Zhang M, Tan W, Gilkeson GS, Tsao BP
Ann Rheum Dis 2022 Dec;81(12):1712-1721. Epub 2022 Aug 17 doi: 10.1136/ard-2022-222795. PMID: 35977808Free PMC Article
Appenzeller S, Pereira DR, Julio PR, Reis F, Rittner L, Marini R
Lancet Child Adolesc Health 2022 Aug;6(8):571-581. doi: 10.1016/S2352-4642(22)00157-2. PMID: 35841921
Brunner HI, Abud-Mendoza C, Viola DO, Calvo Penades I, Levy D, Anton J, Calderon JE, Chasnyk VG, Ferrandiz MA, Keltsev V, Paz Gastanaga ME, Shishov M, Boteanu AL, Henrickson M, Bass D, Clark K, Hammer A, Ji BN, Nino A, Roth DA, Struemper H, Wang ML, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Ann Rheum Dis 2020 Oct;79(10):1340-1348. Epub 2020 Jul 22 doi: 10.1136/annrheumdis-2020-217101. PMID: 32699034Free PMC Article
Wenderfer SE, Eldin KW
Pediatr Clin North Am 2019 Feb;66(1):87-99. doi: 10.1016/j.pcl.2018.08.007. PMID: 30454753
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866

Diagnosis

Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA
Paediatr Drugs 2021 Jul;23(4):331-347. Epub 2021 Jul 10 doi: 10.1007/s40272-021-00457-z. PMID: 34244988Free PMC Article
Wenderfer SE, Eldin KW
Pediatr Clin North Am 2019 Feb;66(1):87-99. doi: 10.1016/j.pcl.2018.08.007. PMID: 30454753
Harry O, Yasin S, Brunner H
J Pediatr 2018 May;196:22-30.e2. doi: 10.1016/j.jpeds.2018.01.045. PMID: 29703361
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Groot N, de Graeff N, Avcin T, Bader-Meunier B, Brogan P, Dolezalova P, Feldman B, Kone-Paut I, Lahdenne P, Marks SD, McCann L, Ozen S, Pilkington C, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Ann Rheum Dis 2017 Nov;76(11):1788-1796. Epub 2017 Jun 19 doi: 10.1136/annrheumdis-2016-210960. PMID: 28630236

Therapy

Pan L, Liu J, Liu C, Guo L, Punaro M, Yang S
Front Immunol 2023;14:1128754. Epub 2023 Aug 10 doi: 10.3389/fimmu.2023.1128754. PMID: 37638017Free PMC Article
Kaneko M, Jackson SW
Pediatr Nephrol 2023 Apr;38(4):1001-1012. Epub 2022 Jul 1 doi: 10.1007/s00467-022-05670-7. PMID: 35778517Free PMC Article
Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA
Paediatr Drugs 2021 Jul;23(4):331-347. Epub 2021 Jul 10 doi: 10.1007/s40272-021-00457-z. PMID: 34244988Free PMC Article
Brunner HI, Abud-Mendoza C, Viola DO, Calvo Penades I, Levy D, Anton J, Calderon JE, Chasnyk VG, Ferrandiz MA, Keltsev V, Paz Gastanaga ME, Shishov M, Boteanu AL, Henrickson M, Bass D, Clark K, Hammer A, Ji BN, Nino A, Roth DA, Struemper H, Wang ML, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
Ann Rheum Dis 2020 Oct;79(10):1340-1348. Epub 2020 Jul 22 doi: 10.1136/annrheumdis-2020-217101. PMID: 32699034Free PMC Article
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866

Prognosis

Xu L, Zhao J, Sun Q, Xu X, Wang L, Liu T, Wu Y, Zhu J, Geng L, Deng Y, Awgulewitsch A, Kamen DL, Oates JC, Raj P, Wakeland EK, Scofield RH, Guthridge JM, James JA, Hahn BH, McCurdy DK, Wang F, Zhang M, Tan W, Gilkeson GS, Tsao BP
Ann Rheum Dis 2022 Dec;81(12):1712-1721. Epub 2022 Aug 17 doi: 10.1136/ard-2022-222795. PMID: 35977808Free PMC Article
Appenzeller S, Pereira DR, Julio PR, Reis F, Rittner L, Marini R
Lancet Child Adolesc Health 2022 Aug;6(8):571-581. doi: 10.1016/S2352-4642(22)00157-2. PMID: 35841921
Wenderfer SE, Eldin KW
Pediatr Clin North Am 2019 Feb;66(1):87-99. doi: 10.1016/j.pcl.2018.08.007. PMID: 30454753
Thorbinson C, Oni L, Smith E, Midgley A, Beresford MW
Paediatr Drugs 2016 Jun;18(3):181-95. doi: 10.1007/s40272-016-0170-8. PMID: 26971103
Borgia RE, Silverman ED
Curr Opin Rheumatol 2015 Sep;27(5):483-92. doi: 10.1097/BOR.0000000000000208. PMID: 26200474

Clinical prediction guides

Xu L, Zhao J, Sun Q, Xu X, Wang L, Liu T, Wu Y, Zhu J, Geng L, Deng Y, Awgulewitsch A, Kamen DL, Oates JC, Raj P, Wakeland EK, Scofield RH, Guthridge JM, James JA, Hahn BH, McCurdy DK, Wang F, Zhang M, Tan W, Gilkeson GS, Tsao BP
Ann Rheum Dis 2022 Dec;81(12):1712-1721. Epub 2022 Aug 17 doi: 10.1136/ard-2022-222795. PMID: 35977808Free PMC Article
Trindade VC, Carneiro-Sampaio M, Bonfa E, Silva CA
Paediatr Drugs 2021 Jul;23(4):331-347. Epub 2021 Jul 10 doi: 10.1007/s40272-021-00457-z. PMID: 34244988Free PMC Article
Giancane G, Rosina S, Consolaro A, Ruperto N
Curr Rheumatol Rep 2021 Mar 8;23(4):23. doi: 10.1007/s11926-021-00988-x. PMID: 33683471
Borgia RE, Silverman ED
Curr Opin Rheumatol 2015 Sep;27(5):483-92. doi: 10.1097/BOR.0000000000000208. PMID: 26200474
Abulaban KM, Brunner HI
Curr Rheumatol Rep 2015 Jan;17(1):471. doi: 10.1007/s11926-014-0471-2. PMID: 25475594Free PMC Article

Recent systematic reviews

Smith EMD, Aggarwal A, Ainsworth J, Al-Abadi E, Avcin T, Bortey L, Burnham J, Ciurtin C, Hedrich CM, Kamphuis S, Levy DM, Lewandowski LB, Maxwell N, Morand EF, Ozen S, Pain CE, Ravelli A, Saad Magalhaes C, Pilkington CA, Schonenberg-Meinema D, Scott C, Tullus K, Beresford MW; cSLE T2T International Task Force
Ann Rheum Dis 2023 Jun;82(6):788-798. Epub 2023 Jan 10 doi: 10.1136/ard-2022-223328. PMID: 36627168Free PMC Article
Ross E, Abulaban K, Kessler E, Cunningham N
Lupus 2022 Jun;31(7):864-879. Epub 2022 Apr 20 doi: 10.1177/09612033221094704. PMID: 35442103Free PMC Article
Santos FPST, Nascimento BR, Calderaro DC, Ferreira GA, Correa H
J Clin Rheumatol 2021 Aug 1;27(5):206-214. doi: 10.1097/RHU.0000000000001029. PMID: 31022053
Schonenberg-Meinema D, Melsens K, Nassar-Sheikh Rashid A, Cutolo M, Kuijpers TW, van den Berg JM, Smith V
Clin Exp Rheumatol 2020 Mar-Apr;38(2):350-354. Epub 2019 Dec 18 doi: 10.55563/clinexprheumatol/azl2bj. PMID: 31858964
Quilter MC, Hiraki LT, Korczak DJ
Lupus 2019 Jun;28(7):878-887. doi: 10.1177/0961203319853621. PMID: 31188723

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