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Skin fissure

MedGen UID:
472943
•Concept ID:
C0221245
•
Finding
Synonyms: Fissuring; Fissuring of skin; Skin fissures
SNOMED CT: Skin fissure (95321009); Rhagades (95321009); Cracks in skin (95321009); Splits in skin (95321009); Fissure in skin (95321009); Rhagades (31478005)
 
HPO: HP:0031057

Definition

A clearly-defined and roughly linear cleavage in the skin that usually extends to the dermis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin fissure

Professional guidelines

PubMed

Effect of chronic anal fissure components on isosorbide dinitrate treatment.
Arslan K, Erenoğlu B, Doğru O, Kökçam S, Turan E, Atay A
World J Surg 2012 Sep;36(9):2225-9. doi: 10.1007/s00268-012-1604-2. PMID: 22526048

Recent clinical studies

Etiology

Potential Efficacy of Shiunko for Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody-Induced Skin Fissure: A Single Institutional Case Series.
Okunaka M, Kotani D, Mishima S, Nakamura M, Kawazoe A, Bando H, Yoshino T, Shitara K
Integr Cancer Ther 2024 Jan-Dec;23:15347354231225962. doi: 10.1177/15347354231225962. PMID: 38240253Free PMC Article
Management of cutaneous toxicities under amivantamab (anti MET and anti EGFR bispecific antibody) in patients with metastatic non-small cell lung cancer harboring EGFR Exon20ins: towards a proactive, multidisciplinary approach.
Basse C, Chabanol H, Bonte PE, Fromantin I, Girard N
Lung Cancer 2022 Nov;173:116-123. Epub 2022 Sep 27 doi: 10.1016/j.lungcan.2022.09.012. PMID: 36198244
Multicenter Phase II study of FOLFOX or biweekly XELOX and Erbitux (cetuximab) as first-line therapy in patients with wild-type KRAS/BRAF metastatic colorectal cancer: The FLEET study.
Soda H, Maeda H, Hasegawa J, Takahashi T, Hazama S, Fukunaga M, Kono E, Kotaka M, Sakamoto J, Nagata N, Oba K, Mishima H
BMC Cancer 2015 Oct 14;15:695. doi: 10.1186/s12885-015-1685-z. PMID: 26467662Free PMC Article
Randomized, open-label trial evaluating the preventive effect of tetracycline on afatinib induced-skin toxicities in non-small cell lung cancer patients.
Arrieta O, Vega-González MT, López-Macías D, Martínez-Hernández JN, Bacon-Fonseca L, Macedo-Pérez EO, Ramírez-Tirado LA, Flores-Estrada D, de la Garza-Salazar J
Lung Cancer 2015 Jun;88(3):282-8. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.019. PMID: 25882778

Diagnosis

A case report of toxic epidermal necrolysis associated with AZD-9291.
Wang J, Cheng X, Lu Y, Zhou B
Drug Des Devel Ther 2018;12:2163-2167. Epub 2018 Jul 11 doi: 10.2147/DDDT.S168248. PMID: 30034220Free PMC Article
Randomized, open-label trial evaluating the preventive effect of tetracycline on afatinib induced-skin toxicities in non-small cell lung cancer patients.
Arrieta O, Vega-González MT, López-Macías D, Martínez-Hernández JN, Bacon-Fonseca L, Macedo-Pérez EO, Ramírez-Tirado LA, Flores-Estrada D, de la Garza-Salazar J
Lung Cancer 2015 Jun;88(3):282-8. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.019. PMID: 25882778
Latex hypersensitivity/glove component reaction as a contributing factor to osteomyelitis of the hand: a case report and review of the literature.
Duplechain MT, Lorio MP
J La State Med Soc 1998 Nov;150(11):527-32. PMID: 9861804

Therapy

Potential Efficacy of Shiunko for Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody-Induced Skin Fissure: A Single Institutional Case Series.
Okunaka M, Kotani D, Mishima S, Nakamura M, Kawazoe A, Bando H, Yoshino T, Shitara K
Integr Cancer Ther 2024 Jan-Dec;23:15347354231225962. doi: 10.1177/15347354231225962. PMID: 38240253Free PMC Article
Management of cutaneous toxicities under amivantamab (anti MET and anti EGFR bispecific antibody) in patients with metastatic non-small cell lung cancer harboring EGFR Exon20ins: towards a proactive, multidisciplinary approach.
Basse C, Chabanol H, Bonte PE, Fromantin I, Girard N
Lung Cancer 2022 Nov;173:116-123. Epub 2022 Sep 27 doi: 10.1016/j.lungcan.2022.09.012. PMID: 36198244
A case report of toxic epidermal necrolysis associated with AZD-9291.
Wang J, Cheng X, Lu Y, Zhou B
Drug Des Devel Ther 2018;12:2163-2167. Epub 2018 Jul 11 doi: 10.2147/DDDT.S168248. PMID: 30034220Free PMC Article
Randomized, open-label trial evaluating the preventive effect of tetracycline on afatinib induced-skin toxicities in non-small cell lung cancer patients.
Arrieta O, Vega-González MT, López-Macías D, Martínez-Hernández JN, Bacon-Fonseca L, Macedo-Pérez EO, Ramírez-Tirado LA, Flores-Estrada D, de la Garza-Salazar J
Lung Cancer 2015 Jun;88(3):282-8. Epub 2015 Mar 28 doi: 10.1016/j.lungcan.2015.03.019. PMID: 25882778
Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects.
Yanagi T, Akiyama M, Nishihara H, Sakai K, Nishie W, Tanaka S, Shimizu H
Hum Mol Genet 2008 Oct 1;17(19):3075-83. Epub 2008 Jul 15 doi: 10.1093/hmg/ddn204. PMID: 18632686

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