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Osteonecrosis of jaw due to bisphosphonate

MedGen UID:
465245
Concept ID:
C3178777
Pathologic Function
Synonyms: Bisphosphonate Associated Osteonecrosis of the Jaw; Bisphosphonate Associated Osteonecrosis of the Jaws; Bisphosphonate Induced Osteonecrosis of the Jaw; Bisphosphonate Induced Osteonecrosis of the Jaws; Bisphosphonate Related Osteonecrosis of the Jaw; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bisphosphonate-Associated Osteonecrosis of the Jaws; Bisphosphonate-Induced Osteonecrosis of the Jaw; Bisphosphonate-Induced Osteonecrosis of the Jaws; Bisphosphonate-Related Osteonecrosis of the Jaw; Osteonecrosis of the Jaw, Bisphosphonate Associated; Osteonecrosis of the Jaw, Bisphosphonate Induced; Osteonecrosis of the Jaw, Bisphosphonate Related; Osteonecrosis of the Jaw, Bisphosphonate-Associated; Osteonecrosis of the Jaw, Bisphosphonate-Induced; Osteonecrosis of the Jaw, Bisphosphonate-Related; Osteonecrosis of the Jaws, Bisphosphonate Associated; Osteonecrosis of the Jaws, Bisphosphonate Induced; Osteonecrosis of the Jaws, Bisphosphonate Related; Osteonecrosis of the Jaws, Bisphosphonate-Associated; Osteonecrosis of the Jaws, Bisphosphonate-Induced; Osteonecrosis of the Jaws, Bisphosphonate-Related
SNOMED CT: Osteonecrosis of jaw due to bisphosphonate (699687003); Bisphosphonate related osteonecrosis of jaw (699687003); Osteonecrosis of jaw caused by bisphosphonate (699687003); Osteonecrosis of jaw caused by diphosphonate (699687003)

Definition

Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteonecrosis of jaw due to bisphosphonate

Professional guidelines

PubMed

Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Recent clinical studies

Etiology

Kuroshima S, Al-Omari FA, Sasaki M, Sawase T
Genesis 2022 Sep;60(8-9):e23500. Epub 2022 Sep 15 doi: 10.1002/dvg.23500. PMID: 36106755
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Diagnosis

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F; American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 2014 Oct;72(10):1938-56. Epub 2014 May 5 doi: 10.1016/j.joms.2014.04.031. PMID: 25234529

Therapy

Kuroshima S, Al-Omari FA, Sasaki M, Sawase T
Genesis 2022 Sep;60(8-9):e23500. Epub 2022 Sep 15 doi: 10.1002/dvg.23500. PMID: 36106755
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Prognosis

Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Limones A, Sáez-Alcaide LM, Díaz-Parreño SA, Helm A, Bornstein MM, Molinero-Mourelle P
Med Oral Patol Oral Cir Bucal 2020 May 1;25(3):e326-e336. doi: 10.4317/medoral.23324. PMID: 32271321Free PMC Article
Dunphy L, Salzano G, Gerber B, Graystone J
BMJ Case Rep 2020 Jan 5;13(1) doi: 10.1136/bcr-2018-224455. PMID: 31907213Free PMC Article
Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, Compston JE, Drake MT, Edwards BJ, Favus MJ, Greenspan SL, McKinney R Jr, Pignolo RJ, Sellmeyer DE
J Bone Miner Res 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. PMID: 26350171Free PMC Article

Clinical prediction guides

Everts-Graber J, Lehmann D, Burkard JP, Schaller B, Gahl B, Häuselmann H, Studer U, Ziswiler HR, Reichenbach S, Lehmann T
J Bone Miner Res 2022 Feb;37(2):340-348. Epub 2021 Nov 30 doi: 10.1002/jbmr.4472. PMID: 34787342
Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Reid IR, Green JR, Lyles KW, Reid DM, Trechsel U, Hosking DJ, Black DM, Cummings SR, Russell RGG, Eriksen EF
Bone 2020 Aug;137:115390. Epub 2020 Apr 27 doi: 10.1016/j.bone.2020.115390. PMID: 32353565
Dunphy L, Salzano G, Gerber B, Graystone J
BMJ Case Rep 2020 Jan 5;13(1) doi: 10.1136/bcr-2018-224455. PMID: 31907213Free PMC Article
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O
Cochrane Database Syst Rev 2017 Oct 6;10(10):CD012432. doi: 10.1002/14651858.CD012432.pub2. PMID: 28983908Free PMC Article

Recent systematic reviews

Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O, Peter JU
Cochrane Database Syst Rev 2022 Jul 12;7(7):CD012432. doi: 10.1002/14651858.CD012432.pub3. PMID: 35866376Free PMC Article
Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, Soares Rocha F
Minerva Dent Oral Sci 2021 Feb;70(1):49-57. Epub 2020 Sep 22 doi: 10.23736/S2724-6329.20.04306-X. PMID: 32960522
de-Freitas NR, Lima LB, de-Moura MB, Veloso-Guedes CC, Simamoto-Júnior PC, de-Magalhães D
Med Oral Patol Oral Cir Bucal 2016 Sep 1;21(5):e644-51. doi: 10.4317/medoral.20920. PMID: 27475681Free PMC Article
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

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