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Poroma

MedGen UID:
404005
•Concept ID:
C2717981
•
Neoplastic Process
Synonyms: Poromas; Poromatoses; Poromatosis
 
HPO: HP:0031405

Definition

A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273]. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoroma

Conditions with this feature

SchC6pf-Schulz-Passarge syndrome
MedGen UID:
347366
•Concept ID:
C1857069
•
Disease or Syndrome
Schopf-Schulz-Passarge syndrome (SSPS) is an autosomal recessive disorder characterized by a constellation of multiple eyelid cysts, hypodontia, hypotrichosis, palmoplantar hyperkeratosis, and onychodystrophy (summary by Mallaiah and Dickinson, 2001).
See: Condition Record
SchC6pf-Schulz-Passarge syndrome

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.
Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908
Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation.
Aslan F, Demirkesen C, Cağatay P, Tüzüner N
J Cutan Pathol 2006 Aug;33(8):531-8. doi: 10.1111/j.1600-0560.2006.00466.x. PMID: 16919026

Recent clinical studies

Etiology

Combined Poroma and Verruca Plantaris.
Kneiber D, Cassarino DS
Am J Dermatopathol 2022 May 1;44(5):e51-e53. doi: 10.1097/DAD.0000000000002123. PMID: 35120031
Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma.
Kawaguchi M, Kato H, Imada H, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
J Comput Assist Tomogr 2021 May-Jun 01;45(3):447-451. doi: 10.1097/RCT.0000000000001146. PMID: 33797441
Characteristic Clinical and Dermoscopic Features of Nonvolar Poroma.
Ha DL, Lee GW, Shin K, Kim HS, Ko HC, Kim BS, Kim MB
J Cutan Med Surg 2021 Mar-Apr;25(2):142-149. Epub 2020 Sep 3 doi: 10.1177/1203475420952432. PMID: 32880198
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Poroma: a review of eccrine, apocrine, and malignant forms.
Sawaya JL, Khachemoune A
Int J Dermatol 2014 Sep;53(9):1053-61. Epub 2014 Apr 2 doi: 10.1111/ijd.12448. PMID: 24697501

Diagnosis

A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Reactive syringofibroadenoma.
Kumar P, Das A, Das PC
Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):681-682. doi: 10.4103/ijdvl.IJDVL_924_18. PMID: 31249214
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Lightning strikes thrice.
McCalmont TH
J Cutan Pathol 2014 Feb;41(2):78-80. doi: 10.1111/cup.12291. PMID: 24460880

Therapy

Eccrine poromatosis following chemotherapy and radiation therapy.
Nguyen K, Kim G, Chiu M
Dermatol Online J 2019 Nov 15;25(11) PMID: 32045152
Eccrine poromatosis associated with polychemotherapy.
Fujii K, Aochi S, Takeshima C, Ohtsuka M, Hamada T, Asagoe K, Aoyama Y, Morizane S, Iwatsuki K
Acta Derm Venereol 2012 Nov;92(6):687-90. doi: 10.2340/00015555-1279. PMID: 22294042
The epidemiology of malaria in the Papua New Guinea highlands: 7. Southern Highlands Province.
Maraga S, Plüss B, Schöpflin S, Sie A, Iga J, Ousari M, Yala S, Meier G, Reeder JC, Mueller I
P N G Med J 2011 Mar-Jun;54(1-2):35-47. PMID: 23763037
Eccrine porocarcinoma.
Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620
New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma.
Langbein L, Cribier B, Schirmacher P, Praetzel-Wunder S, Peltre B, Schweizer J
Br J Dermatol 2008 Sep;159(3):633-45. Epub 2008 Jul 19 doi: 10.1111/j.1365-2133.2008.08746.x. PMID: 18647305

Prognosis

Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update.
Kervarrec T, Pissaloux D, Tirode F, de la Fouchardière A, Sohier P, Frouin E, Hamard A, Houben R, Schrama D, Barlier A, Cribier B, Battistella M, Macagno N
Histopathology 2024 Jan;84(2):266-278. Epub 2023 Aug 23 doi: 10.1111/his.15023. PMID: 37609771
Dermoscopy for the Identification of Amelanotic Acral Melanoma.
Koblinski JE, Ahrns HT, Morse MJ, Seiverling EV
J Am Podiatr Med Assoc 2022 Mar 16;112(1) doi: 10.7547/20-184. PMID: 36459055
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases.
Le NS, Janik S, Liu DT, Grasl S, Faisal M, Pammer J, Schickinger-Fischer B, Hamzavi JS, Seemann R, Erovic BM
Head Neck 2020 Sep;42(9):2644-2659. Epub 2020 Apr 21 doi: 10.1002/hed.26178. PMID: 32314845
Senile Purpura as a Stage of Dermatoporosis.
Karadag AS, Parish LC, Lambert WC
Skinmed 2017;15(2):91-92. Epub 2017 Apr 1 PMID: 28528600

Clinical prediction guides

Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma.
Kawaguchi M, Kato H, Imada H, Miyazaki T, Matsuyama K, Seishima M, Matsuo M
J Comput Assist Tomogr 2021 May-Jun 01;45(3):447-451. doi: 10.1097/RCT.0000000000001146. PMID: 33797441
Characteristic Clinical and Dermoscopic Features of Nonvolar Poroma.
Ha DL, Lee GW, Shin K, Kim HS, Ko HC, Kim BS, Kim MB
J Cutan Med Surg 2021 Mar-Apr;25(2):142-149. Epub 2020 Sep 3 doi: 10.1177/1203475420952432. PMID: 32880198
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Recent systematic reviews

A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261

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