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Laryngeal Basaloid Carcinoma

MedGen UID:
353839
•Concept ID:
C1708650
•
Neoplastic Process

Definition

An aggressive variant of squamous cell carcinoma that arises from the pyriform sinus or supraglottic area. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. An in situ or invasive keratinizing squamous cell carcinoma component is always present. Signs and symptoms include hoarseness, dysphagia, pain, and neck mass. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Basaloid Carcinoma

Professional guidelines

PubMed

The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

Recent clinical studies

Etiology

Transoral laryngeal microsurgery for early-stage laryngeal basaloid squamous cell carcinoma.
Verro B, Saraniti C
BMJ Case Rep 2021 Dec 30;14(12) doi: 10.1136/bcr-2021-245746. PMID: 34969794Free PMC Article
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
The basaloid variant of squamous cell carcinoma of the larynx.
Tutar H, Aydil U, Ekinci O, Bakkal FK, Tutar VB, Kizil Y, Ugur MB
Braz J Otorhinolaryngol 2014 May-Jun;80(3):245-50. doi: 10.1016/j.bjorl.2014.02.005. PMID: 25153110Free PMC Article
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Basaloid squamous cell carcinoma of the head and neck: report of 18 cases.
Choussy O, Bertrand M, François A, Blot E, Hamidou H, Dehesdin D
J Laryngol Otol 2011 Jun;125(6):608-13. Epub 2011 Mar 30 doi: 10.1017/S0022215111000491. PMID: 21450130

Diagnosis

Transoral laryngeal microsurgery for early-stage laryngeal basaloid squamous cell carcinoma.
Verro B, Saraniti C
BMJ Case Rep 2021 Dec 30;14(12) doi: 10.1136/bcr-2021-245746. PMID: 34969794Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131
Not your usual cancer case: variants of laryngeal squamous cell carcinoma.
Lewis JS Jr
Head Neck Pathol 2011 Mar;5(1):23-30. Epub 2010 Dec 17 doi: 10.1007/s12105-010-0232-0. PMID: 21165725Free PMC Article

Therapy

Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.
Koyama S, Fujiwara K, Morisaki T, Fujii T, Nakamura Y, Fukuhara T, Takeuchi H
Auris Nasus Larynx 2021 Dec;48(6):1189-1192. Epub 2020 Jul 16 doi: 10.1016/j.anl.2020.07.002. PMID: 32684403
Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage.
Escher P, Bu L, Cayci Z, Yueh B, Li F
Head Neck Pathol 2020 Sep;14(3):771-777. Epub 2019 Dec 23 doi: 10.1007/s12105-019-01119-w. PMID: 31873935Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181
Different risk factors in basaloid and common squamous head and neck cancer.
Kleist B, Bankau A, Lorenz G, Jäger B, Poetsch M
Laryngoscope 2004 Jun;114(6):1063-8. doi: 10.1097/00005537-200406000-00020. PMID: 15179214

Prognosis

Transoral laryngeal microsurgery for early-stage laryngeal basaloid squamous cell carcinoma.
Verro B, Saraniti C
BMJ Case Rep 2021 Dec 30;14(12) doi: 10.1136/bcr-2021-245746. PMID: 34969794Free PMC Article
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.
Koyama S, Fujiwara K, Morisaki T, Fujii T, Nakamura Y, Fukuhara T, Takeuchi H
Auris Nasus Larynx 2021 Dec;48(6):1189-1192. Epub 2020 Jul 16 doi: 10.1016/j.anl.2020.07.002. PMID: 32684403
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Basaloid squamous cell carcinoma of the head and neck: report of 18 cases.
Choussy O, Bertrand M, François A, Blot E, Hamidou H, Dehesdin D
J Laryngol Otol 2011 Jun;125(6):608-13. Epub 2011 Mar 30 doi: 10.1017/S0022215111000491. PMID: 21450130
Basaloid squamous carcinoma of the larynx.
Bahar G, Feinmesser R, Popovtzer A, Ulanovsky D, Nageris B, Marshak G, Feinmesser M
Am J Otolaryngol 2003 May-Jun;24(3):204-8. doi: 10.1016/s0196-0709(03)00004-8. PMID: 12761712

Clinical prediction guides

Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.
Prieto-Granada CN, Xu B, Alzumaili B, Al Rasheed MRH, Eskander A, Enepekides D, Patel SG, Stevens TM, Dogan S, Ghossein R, Katabi N
Virchows Arch 2021 Oct;479(4):729-739. Epub 2021 May 12 doi: 10.1007/s00428-021-03117-2. PMID: 33982148Free PMC Article
Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.
Koyama S, Fujiwara K, Morisaki T, Fujii T, Nakamura Y, Fukuhara T, Takeuchi H
Auris Nasus Larynx 2021 Dec;48(6):1189-1192. Epub 2020 Jul 16 doi: 10.1016/j.anl.2020.07.002. PMID: 32684403
Basaloid squamous cell carcinoma arising in an inverted papilloma in the nasal cavity: A case report and review.
Koyama S, Nakamura Y, Yokoyama Y, Morisaki T, Fukuhara T, Fujiwara K, Kitano H, Takeuchi H
Auris Nasus Larynx 2017 Oct;44(5):624-628. Epub 2016 Oct 7 doi: 10.1016/j.anl.2016.09.005. PMID: 27720480
Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus.
Mehrad M, Carpenter DH, Chernock RD, Wang H, Ma XJ, Luo Y, Luo J, Lewis JS Jr, El-Mofty SK
Am J Surg Pathol 2013 Sep;37(9):1349-56. doi: 10.1097/PAS.0b013e318290427d. PMID: 23797720Free PMC Article
Basaloid squamous cell carcinoma of the larynx and hypopharynx.
Ferlito A, Altavilla G, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1997 Dec;106(12):1024-35. doi: 10.1177/000348949710601206. PMID: 9415598

Recent systematic reviews

Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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