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Laryngeal Acantholytic Squamous Cell Carcinoma

MedGen UID:
313337
•Concept ID:
C1708648
•
Neoplastic Process

Definition

A rare variant of squamous cell carcinoma that arises from the larynx. It is characterized by acantholysis of the tumor cells that results in the formation of pseudolumina that resemble glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Acantholytic Squamous Cell Carcinoma

Professional guidelines

PubMed

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

Recent clinical studies

Etiology

Laryngeal malignancies - epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016-July 2020).
Sitaru AM, Flondor D, Dinu Ş, Horhat ID, Iftode OA, Poenaru M, Balica NC, Baderca F, Georgescu D, Chioran D, Sarău CA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):153-160. doi: 10.47162/RJME.63.1.16. PMID: 36074679Free PMC Article
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature.
Sajin M, Hodorogea Prisăcaru A, Luchian MC, Pătraşcu OM, Dumitru A, Costache D, Dumitrescu D, Vrînceanu D, Voinea LM, Simionescu O, Costache M
Rom J Morphol Embryol 2014;55(2):279-83. PMID: 24969975

Diagnosis

Laryngeal malignancies - epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016-July 2020).
Sitaru AM, Flondor D, Dinu Ş, Horhat ID, Iftode OA, Poenaru M, Balica NC, Baderca F, Georgescu D, Chioran D, Sarău CA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):153-160. doi: 10.47162/RJME.63.1.16. PMID: 36074679Free PMC Article
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M
APMIS 2006 Jun;114(6):470-3. doi: 10.1111/j.1600-0463.2006.apm_376.x. PMID: 16856971

Prognosis

Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M
APMIS 2006 Jun;114(6):470-3. doi: 10.1111/j.1600-0463.2006.apm_376.x. PMID: 16856971

Clinical prediction guides

Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M
APMIS 2006 Jun;114(6):470-3. doi: 10.1111/j.1600-0463.2006.apm_376.x. PMID: 16856971

Supplemental Content

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